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slcimmuno Member Level Tuesday, 05/30/17 01:51:33 PM
Re: None
Post # of 183664

like CAR-T, and now: CRISPR... Red Flags... "First Do No Harm"

compare these findings with non-genotoxic Kevetrin; just need to get that Oral formulation done, and along the way, learn more about its MOA

http://www.genengnews.com/gen-news-highlights...e/81254419

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The CRISPR/Cas9 genome-editing technique set the molecular biology field ablaze when its game-changing potential was realized only a few short years ago. In the time since this wildfire of excitement and hope, it has spread to almost every life science endeavor imaginable and shows little sign of slowing down. However, new data from a team of scientists lead by investigators at Columbia University Medical Center (CUMC) has uncovered that the gene-editing technology can introduce hundreds of unintended mutations into the genome—a concerning find, considering the technology is beginning to move full steam ahead into clinical trials. The findings from the new study were published recently in Nature Methods in an article entitled "Unexpected Mutations after CRISPR-Cas9 Editing In Vivo."

“We feel it's critical that the scientific community consider the potential hazards of all off-target mutations caused by CRISPR, including single-nucleotide mutations and mutations in noncoding regions of the genome," explained study co-author Stephen Tsang, M.D., Ph.D., associate professor of ophthalmology, pathology, and cell biology at CUMC, Columbia's Institute of Genomic Medicine, and the Institute of Human Nutrition.

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