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Posted On: 03/04/2017 3:45:52 PM
Post# of 72444
K reactivated p53 in glioblastoma cell line (U-87 MG), but that was in vitro. Yesterday's PR seems to be in vivo, which is really exciting because human Gliobastoma Multiforme (hGBM) is the most aggressive form of brain cancers.
I don't think K can cross the BBB on its own because it's water-soluble. Water-soluble substances such as penicillin can't cross the BBB. It's possible that U of B figured out a way to use transport proteins to help K crosses the BBB, similar to the way Glucose is transported by GLUT-1.
Hopefully Leo will share the preclinical data presented at future conferences. I'm really curious about how K crosses the BBB.
I don't think K can cross the BBB on its own because it's water-soluble. Water-soluble substances such as penicillin can't cross the BBB. It's possible that U of B figured out a way to use transport proteins to help K crosses the BBB, similar to the way Glucose is transported by GLUT-1.
Hopefully Leo will share the preclinical data presented at future conferences. I'm really curious about how K crosses the BBB.
Quote:
Does anyone know if K crosses the Blood Brain Barrier?
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