Posted On: 07/24/2016 8:05:08 PM
Post# of 72447
Someone asked me a question about the bioequivance of Prurisol to Ziagen and here's my answer.
350 mg of Prurisol was proven to be bioequivalent to 300 mg of Ziagen in Phase 1. The bioavailability is 25% for P and 83% for Z, meaning that 87.5 mg of P and 249 mg of Z will reach the systemic circulation.
If 249 mg of P needs to reach the systemic circulation, one would need to take almost 1000 mg of P. Here's my calculations.
249 mg (Z) / 87.5 mg (P) = 2.85
350 mg (P) * 2.85 = 997.5 mg
997.5 mg (P) * 0.25 (bioavailability) = 249 mg (P)
200 mg of P was shown to be effective in Phase 2a. Even at 400 mg, P is still half of Z in bioavailability.
350 mg of Prurisol was proven to be bioequivalent to 300 mg of Ziagen in Phase 1. The bioavailability is 25% for P and 83% for Z, meaning that 87.5 mg of P and 249 mg of Z will reach the systemic circulation.
If 249 mg of P needs to reach the systemic circulation, one would need to take almost 1000 mg of P. Here's my calculations.
249 mg (Z) / 87.5 mg (P) = 2.85
350 mg (P) * 2.85 = 997.5 mg
997.5 mg (P) * 0.25 (bioavailability) = 249 mg (P)
200 mg of P was shown to be effective in Phase 2a. Even at 400 mg, P is still half of Z in bioavailability.
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