This is also speculating that by adding an additional drug or treatment "agents" to the host to increase Treg cells, this anti-rejection or "tolerance" could facilitate an even longer lasting "loop" of healthy integration of the transplant. And also, as NEW4 stated, "limitations" of current immune suppressants would be a thing of the past. Which is great! These limitations can be the downfall of quality of life for some that live through organ transplants.

Quote:

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Indeed the possibility of amplifying such tolerogenic loops by administration
of agents that increase the number of Treg cells, which has previously been clinically applied
using non-Fc binding antiCD3 [45], may be assessed in future experiments to augment the
tolerogenic process.
In conclusion, the current paper provides proof of concept for the utilization of siRNA in
modifying recipient responses to allogeneic transplantation. The possibility of inhibiting
chronic rejection through targeting the indirect pathway of antigen presentation suggests a
possibility to overcome limitations of current immune suppressants.

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