Lyra Therapeutics Shares Key Findings on LYR-210 for CRS

Lyra Therapeutics Unveils 52-Week Results for LYR-210

Lyra Therapeutics, Inc. (Nasdaq: LYRA), a company pioneering advanced biotechnology options for chronic rhinosinusitis (CRS), is set to reveal significant findings from the 52-week Extension Stage of their ENLIGHTEN 1 Phase 3 study for LYR-210 during the upcoming Combined Otolaryngology Spring Meetings (COSM 2025). The event will take place in New Orleans from May 14 to May 18.

Promising Outcomes for CRS Patients

The presentation at COSM will highlight how LYR-210 has shown a favorable safety profile and results that align with the Primary Study Phase outcomes. The data relates specifically to patients suffering from CRS, a condition that affects a vast number of individuals and can result in serious respiratory complications.

Notably, the study has revealed that patients, particularly those within the subgroup experiencing nasal polyps, showed not only symptomatic improvements but also reductions in polyp size following their treatment with LYR-210. This signifies a strong potential for LYR-210 as an effective long-term treatment option for CRS patients.

High Expectations from the ENLIGHTEN Program

Lyra is also placing emphasis on the forthcoming ENLIGHTEN 2 pivotal Phase 3 trial results anticipated in the second quarter of the year. The trials encompass rigorous evaluations aimed at understanding the full range of LYR-210's effects and its applicability for patients who have not responded to existing therapies.

Key Highlights from the ENLIGHTEN 1 Study

The data set to be shared during this crucial presentation encompasses various critical outcomes:

• Through 52 weeks, LYR-210 was well-tolerated, with no severe adverse events linked to the treatment.
• Patients exhibited sustained symptom relief even after the cessation of LYR-210 treatment.
• Enhanced symptom control was further confirmed in crossover patients transitioning from sham treatment to LYR-210.
• Notably, in the subgroup with nasal polyps, patients switching from sham to LYR-210 experienced significant improvements comparable to those observed in the initial treatment phase.

Details of the Poster Presentation

The poster titled LYR-210 Sinonasal Corticosteroid Implants for Chronic Rhinosinusitis: 52-week outcomes from the Phase 3 ENLIGHTEN 1 trial is scheduled for display in the Elite Exhibit Hall at the Hyatt Regency New Orleans. Attendees will have the opportunity to engage with the data on:

• Date and Time: Poster Sessions on Friday, May 16, from 9:00 a.m. to 7:00 p.m. CT, and Saturday, May 17, from 9:00 a.m. to 4:00 p.m. CT.

About LYR-210

LYR-210 stands as Lyra's flagship product candidate, intended as a treatment for CRS in patients who have seen little to no improvement from conventional therapies. This bioabsorbable nasal implant promises ongoing anti-inflammatory therapy over a six-month period, making it a game-changer for the chronic condition that affects millions. The innovative design allows for an easy in-office procedure, reinforcing accessibility for those in need.

Lyra Therapeutics’ Mission

Lyra Therapeutics is dedicated to addressing the plight of CRS patients, with their innovative treatments aiming to provide relief from debilitating symptoms. With LYR-210 under advanced clinical development, the company is on the forefront of a key transformation in how CRS is managed. They aim to provide solutions to an estimated four million patients in the United States who experience treatment failures annually.

Frequently Asked Questions

What is the purpose of the ENLIGHTEN 1 study?

The ENLIGHTEN 1 study aims to evaluate the efficacy and safety of LYR-210 in chronic rhinosinusitis patients to understand its long-term benefits.

What results will Lyra present at COSM 2025?

Lyra will share findings from the 52-week Extension Stage, demonstrating the safety profile and clinical improvements in CRS patients.

How does LYR-210 work?

LYR-210 is a bioabsorbable nasal implant delivering mometasone furoate, providing prolonged anti-inflammatory treatment for CRS.

What are the implications of the study findings?

The study suggests that LYR-210 could significantly improve the management of CRS, particularly for patients unresponsive to current therapies.

How can I learn more about Lyra Therapeutics?

For more information about their products and ongoing studies, you can visit their official website or follow them on social media.

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