Lexicon Pharmaceuticals Discusses Innovative Pain Management Data

Upcoming Presentation on Diabetic Peripheral Neuropathic Pain

Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX) is set to present significant findings related to diabetic peripheral neuropathic pain (DPNP) at an important annual medical meeting. This presentation aims to highlight the patient-reported outcomes concerning DPNP, emphasizing the critical need for improved therapies. The event will take place during the 7th Annual Meeting of the American Society of Pain and Neuroscience (ASPN 2025), where notable medical professionals and researchers converge to discuss advancements in pain management and treatment strategies.

The Burden of Diabetic Peripheral Neuropathic Pain

DPNP is a common yet often neglected condition that can severely impact the quality of life for those affected. Many patients experience burning sensations, numbness, and other distressing symptoms across various parts of their bodies, including the limbs. It is estimated that around 9 million individuals in the U.S. live with this debilitating condition. Research indicates that DPNP affects approximately 30% of individuals with type 1 diabetes and around 50% of those with type 2 diabetes, illustrating the urgent need for better management and treatment options.

Voicing Patient Experiences

In the words of M. Belinda Hardin, PharmD, BCPS, from Lexicon Pharmaceuticals, the study aims to provide a platform for the voices of almost 100 million people globally who suffer from DPNP. The findings are expected to illuminate the challenges faced by patients in managing their condition, and promote awareness among healthcare providers. The ultimate goal is to empower both patients and their caregivers to engage in meaningful discussions regarding available treatment options.

Presentation Highlights

The presentation titled “Listening to Patients with Diabetic Peripheral Neuropathic Pain: Insights from a Patient Survey to Inform Advanced Clinical Development of Pilavapadin” is scheduled for Saturday, July 19, from 9:40 AM to 10:00 AM ET. It will take place at Poster #125 in the Sparkle Ballroom and will be presented by M. Belinda Hardin, who is involved with U.S. Medical Affairs at Lexicon Pharmaceuticals.

Pilavapadin: A Novel Approach to Pain Management

Pilavapadin (LX9211) represents a groundbreaking advancement in the management of neuropathic pain. It was developed through Lexicon's advanced gene science methodologies, making it a selectively focused, orally administered investigational drug. This innovative compound acts as a small molecule inhibitor of AAK1, a newly identified target for neuropathic pain. Pilavapadin differentiates itself by blocking neurotransmitters involved in pain signaling while preserving the integrity of opiate pathways, presenting a promising alternative for those seeking pain relief.

Phase 2a Study Results

Preclinical studies conducted on pilavapadin have demonstrated its potential efficacy in penetrating the central nervous system and reducing painful behavior in models of neuropathic pain. Furthermore, the Phase 2a proof-of-concept RELIEF-DPN-1 study showed that pilavapadin notably met its primary endpoint, achieving a reduction in Average Daily Pain Score (ADPS) at week six compared to placebo. This research highlights substantial benefits in alleviating symptoms associated with DPNP, including reducing burning pain and sleep disturbances caused by pain. The U.S. Food and Drug Administration has also granted Fast Track designation for namely 'de novo' development of this promising compound.

About Lexicon Pharmaceuticals

Lexicon Pharmaceuticals is dedicated to revolutionizing healthcare through innovative drug development aimed at transforming the lives of patients facing various conditions. Their Genome5000™ program exemplifies Lexicon’s commitment to studying the functionality of approximately 5,000 genes, successfully identifying over 100 protein targets that hold significant therapeutic promise across a wide array of diseases. Their ongoing research and development focus includes areas such as neuropathic pain, hypertrophic cardiomyopathy (HCM), obesity, and metabolic disorders, with several drug candidates showing great promise.

For More Information

For inquiries related to investments or media, individuals can reach out to Lisa DeFrancesco at Lexicon Pharmaceuticals. For further assistance, please send an email to lexinvest@lexpharma.com.

Frequently Asked Questions

What is the primary focus of Lexicon's upcoming presentation?

The presentation will focus on patient-reported outcomes associated with diabetic peripheral neuropathic pain (DPNP).

Why is DPNP a significant concern?

DPNP affects millions of patients, causing debilitating symptoms that diminish their quality of life.

What is pilavapadin and how does it work?

Pilavapadin is a novel small molecule inhibitor that targets AAK1, designed to alleviate neuropathic pain without affecting opiate pathways.

What were the results of the Phase 2a study?

The Phase 2a study demonstrated a significant reduction in average daily pain scores compared to placebo, highlighting its potential efficacy.

How can I get in touch with Lexicon Pharmaceuticals?

You can contact Lexicon through their investor relations email at lexinvest@lexpharma.com.

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