LEO Pharma Showcases Innovative Anzupgo Cream at EADV 2024
LEO Pharma's Significant Contribution to Chronic Hand Eczema Management
At EADV 2024, LEO Pharma A/S, a prominent player in medical dermatology, unveiled critical data on Anzupgo® (delgocitinib) cream through their presentation of the DELTA FORCE trial. This pivotal event showcased findings that could reshape treatment approaches for adults with moderate to severe chronic hand eczema (CHE), particularly for those inadequately addressed by topical corticosteroids.
Insightful Findings from the DELTA FORCE Trial
The DELTA FORCE trial, a rigorous 12-week head-to-head phase 3 study involving 513 participants, was designed to assess the efficacy and safety of delgocitinib cream versus oral alitretinoin capsules. This research highlighted delgocitinib cream's ability to achieve a significantly greater improvement in Hand Eczema Severity Index (HECSI) scores compared to its counterpart.
Key Results of the DELTA FORCE Trial
The primary outcome of reduced HECSI score demonstrated that delgocitinib cream achieved a mean decrease of 67.6, markedly higher than the 51.5 observed with alitretinoin (P<0.001). In addition, a noticeable percentage of patients using delgocitinib cream reported treatment success after 12 weeks, indicating the cream's superior performance in managing symptoms of CHE.
Comprehensive Data Presentation at EADV 2024
The findings shared during this congress represented just a fraction of LEO Pharma’s extensive scientific program. Alongside the DELTA FORCE results, the company launched six additional abstracts, emphasizing the multifactorial and heterogeneous nature of CHE.
Real-world Impact of Chronic Hand Eczema
Real-world evidence highlights that many patients face unique challenges given the diverse nature of CHE, including various symptoms and potential comorbidities. The recent studies reveal not only the objective data of trial outcomes but also insights into the quality of life implications for those living with CHE.
Promising Insights from Additional Research
Among the noteworthy presentations was a post hoc analysis that investigated the efficacy of delgocitinib cream across five distinct CHE subtypes. Furthermore, a population-based CHECK study depicted how patient quality of life diminishes with each treatment step. Qualitative interviews reveal that nearly all patients note a significant burden of living with CHE.
LEO Pharma’s Role in Advancing CHE Treatments
As the global landscape of dermatology evolves, LEO Pharma remains at the forefront, striving to address the unmet medical needs associated with chronic hand eczema. The potential transition to delgocitinib cream as a cornerstone treatment option reflects the company's commitment to improving patient outcomes.
About Anzupgo® (delgocitinib) Cream
Anzupgo® cream, a pan-Janus kinase inhibitor, demonstrates promising benefits for patients with moderate to severe CHE who respond poorly to traditional topical therapies. Utilizing innovative mechanisms, this cream acts on key inflammatory pathways, which are crucial in the pathogenesis of CHE.
About LEO Pharma
With a rich history dating back to 1908, LEO Pharma has dedicated itself to pioneering advancements in the dermatological field. The company's history of innovation and research underlies its commitment to the community, resulting in a broad spectrum of therapies for various skin conditions. Located in Denmark, LEO Pharma employs approximately 4,200 individuals worldwide, serving millions of patients and achieving net sales of DKK 11.4 billion in recent years.
Frequently Asked Questions
What is the DELTA FORCE trial?
The DELTA FORCE trial is a phase 3 clinical trial that compared the efficacy and safety of delgocitinib cream with oral alitretinoin capsules in adults with severe chronic hand eczema.
What were the key findings of the DELTA FORCE trial?
Delgocitinib cream showed a significantly greater decrease in Hand Eczema Severity Index (HECSI) scores compared to alitretinoin, indicating its effectiveness in treating severe chronic hand eczema.
How does Anzupgo® cream work?
Anzupgo® cream is a pan-Janus kinase inhibitor that interrupts key inflammatory signaling pathways involved in chronic hand eczema.
What significance do the EADV 2024 presentations hold?
The presentations at EADV 2024, including results from various studies, underscore the urgency of developing effective treatments for chronic hand eczema and the innovative strides LEO Pharma is making in this field.
How can patients benefit from delgocitinib cream?
Patients can potentially experience better management of chronic hand eczema with delgocitinib cream, as clinical data suggest improved efficacy and safety compared to existing treatments.
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