Kronos Bio Showcases p300 KAT Inhibition Research for Inflammation
Groundbreaking Data Presentation by Kronos Bio at ACR Convergence 2024
Through selective inhibition of proinflammatory transcription, Kronos Bio, Inc. (Nasdaq: KRON) aims to modulate various pro-inflammatory signaling pathways that contribute to chronic inflammatory diseases. This innovative approach holds potential for enhancing anti-inflammatory therapies.
Key Insights into p300 KAT Inhibition
As part of its commitment to addressing deregulated transcription, Kronos Bio will present preclinical data highlighting the significance of its p300 KAT inhibitor program, particularly for autoimmune conditions. The American College of Rheumatology's annual meeting, ACR Convergence 2024, serves as the platform for this significant presentation.
Exploring Therapeutic Potential
The role of interferon regulatory factor 4 (IRF4) and p300 in immune cells such as B and T cells is pivotal in the development of therapeutic strategies. The data showcased at ACR Convergence will underpin the role of p300 as a crucial player in inflammation management.
Presentation Details
The abstract titled "p300 KAT Inhibition Selectively Targets Multiple Cell Types Involved in Chronic Inflammation and Downregulates Key Inflammatory Cytokines" will be presented by Dr. Peter Rahl, Vice President of Discovery Biology. The session is scheduled to take place on Monday, with the specifics as follows:
Abstract Number: 2598
Poster Session: Cytokines & Cell Trafficking
Development Candidate Announcement on the Horizon
Kronos Bio is poised to announce a development candidate intended to target autoimmune diseases by the end of the year. This is a significant step towards providing potential solutions for patients facing chronic inflammatory conditions.
Insight from Leadership
Dr. Peter Rahl elaborated on the company’s innovative methodology, emphasizing their proprietary discovery engine that decodes complex transcription factor regulatory networks to understand and develop effective treatments. He expressed optimism regarding the findings presented at the upcoming ACR event, noting how p300 KAT inhibition can modulate key pathways causing inflammation.
About Kronos Bio
Kronos Bio, Inc. is dedicated to creating therapeutics aimed at transforming the treatment of deregulated transcription, a major factor in cancers and other complex diseases. Their ability to identify druggable cofactors and optimize small molecules uniquely positions them in the pharmaceutical landscape.
With a focus on innovative therapies, Kronos Bio has two internally developed drug candidates: KB-0742 targets CDK9 to combat MYC deregulation, and KB-9558 targets p300 in addressing IRF4 dependence in multiple myeloma.
Conclusion: Looking Ahead
As Kronos Bio gears up for its presentation at ACR Convergence 2024, the excitement surrounding their groundbreaking research and potential advancements in anti-inflammatory therapies merges with anticipation of future developments in the treatment landscape for autoimmune diseases.
Frequently Asked Questions
What is Kronos Bio presenting at ACR Convergence 2024?
Kronos Bio will present preclinical data on its p300 KAT inhibitor program focusing on autoimmune indications at the ACR Convergence 2024 conference.
Who is the presenter of the data at the conference?
The presentation will be led by Dr. Peter Rahl, the Vice President of Discovery Biology at Kronos Bio.
What is p300 KAT inhibition and its significance?
p300 KAT inhibition involves targeting specific proteins to modulate inflammatory signaling pathways, which could lead to therapeutic approaches for managing chronic inflammation.
When and where will the presentation occur?
The presentation is scheduled for Monday, November 18, 2024, during the ACR Convergence 2024 held in Washington, D.C.
What are the future plans for Kronos Bio?
Kronos Bio aims to announce a development candidate targeting autoimmune diseases by the end of 2024, highlighting their commitment to addressing complex therapeutic needs.
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