KBI Biopharma Collaborates with Alanis on Antibody Development

KBI Biopharma Collaborates with Alanis Therapeutics

KBI Biopharma, Inc., a global cGMP contract development and manufacturing organization (CDMO) and a part of JSR Life Sciences, has entered into a significant partnership with Alanis Therapeutics, Inc. This collaboration marks a pivotal step in the development of an innovative therapeutic antibody aimed at treating myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), two challenging blood cancers that affect many individuals worldwide.

Overview of the Agreement

Under the terms of the agreement, KBI will take the lead in various aspects of the therapeutic process, including cell line development and process optimization. Their expertise will ensure effective analytical and formulation development, as well as the manufacturing of Alanis’ pre-clinical antagonistic antibody. KBI aims to utilize its SUREmAb™ platform to produce the antibody efficiently and strategically, facilitating a streamlined and optimized mAb production process essential for clinical trials.

Innovative Technologies in Action

KBI's SUREmAb™ technology is designed for high efficiency in monoclonal antibody development and manufacturing. The platform enables KBI to expedite the transition from cell line transfection to the final phases of cGMP drug substance production. This efficiency is vital for Alanis as they aim to get their lead antibody into clinical trials more swiftly.

Expert Insights

Dr. Robert Goodenow, CEO of Alanis Therapeutics, expressed enthusiasm for the collaboration, stating: "We are pleased to select KBI as our trusted CDMO to advance our lead antibody to the Notch pathway. By collaborating with KBI, we aim to accelerate the development process and move closer to evaluating the full potential of our antibody in clinical trials.” This sentiment highlights the commitment to harnessing innovative therapies for patient benefit.

KBI's Commitment to Quality and Efficiency

Tim Lowery, CEO of KBI Biopharma, reinforced the company’s dedication by saying: "We are proud to support Alanis and spearhead the development of its lead target. Our advanced platforms are optimized to streamline manufacturing, and with our SUREmAb™ technology at the forefront, our integrated workflow can significantly reduce development time." This commitment to quality and efficiency demonstrates KBI's leadership in the biopharma sector and its effectiveness in fostering innovative healthcare solutions.

About KBI Biopharma

KBI Biopharma, a subsidiary of JSR Life Sciences, stands as a global leader in providing integrated drug development and biologics manufacturing services. With an expansive expertise in cell line development, KBI works alongside life science companies to fast-track the discovery and delivery of innovative drugs and vaccines. This partnership model has allowed KBI to support the advancement of over 170 drug candidates, pushing boundaries in preclinical and clinical stages of development.

The Future of Monoclonal Antibodies

The SUREmAb™ platform focuses on maximizing efficiency and maintaining high-quality standards throughout the mAb development process. KBI's approach signifies a shift toward more effective practices in drug manufacturing, as it allows for high-producing mammalian-based cell lines designed for therapeutic protein development to be produced at scale.

The Role of Alanis Therapeutics

Alanis Therapeutics, based in San Diego, aims to address the unmet medical needs presented by cancer and autoimmune diseases. Their flagship program, which has received accolades from organizations such as the V Foundation, focuses on developing antibody therapies that target fundamental pathways driving cancer progression. This innovative approach, especially with their lead candidate targeting Notch 1, represents a promising breakthrough in treatment strategies for MDS and AML.

Conclusion

The collaboration between KBI Biopharma and Alanis Therapeutics exemplifies the commitment of both companies to advance treatment options for serious diseases. By leveraging KBI's specialized manufacturing platforms and Alanis’ groundbreaking therapeutic approaches, they are set to make significant strides in oncology.

Frequently Asked Questions

1. What is the focus of KBI Biopharma?

KBI Biopharma focuses on contract development and manufacturing services in the life sciences sector, specializing in biologics.

2. What type of collaboration has KBI formed with Alanis Therapeutics?

KBI has entered a partnership to develop a therapeutic antibody aimed at treating blood cancers like MDS and AML.

3. What is the SUREmAb™ technology?

SUREmAb™ is KBI's platform for optimizing the development and manufacturing of monoclonal antibodies.

4. Where is Alanis Therapeutics located?

Alanis Therapeutics is based in San Diego, California.

5. What diseases are targeted by Alanis Therapeutics’ lead antibody?

The lead antibody from Alanis Therapeutics aims to treat myelodysplastic syndromes and acute myeloid leukemia.

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