Karyopharm Welcomes Lori Macomber as New CFO on Board

Karyopharm's Strategic Leadership Change

Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a leading name in cancer treatment innovations, has announced a significant addition to its executive team. Lori Macomber is joining the organization as the Chief Financial Officer, a pivotal role that emphasizes Karyopharm's commitment to growth in the dynamic pharmaceutical landscape.

Lori Macomber's Vision for Financial Leadership

In her new position, Lori Macomber will not only take on the responsibilities of Chief Financial Officer but also serve as Executive Vice President and Treasurer. Her extensive background in finance, combined with her strategic mindset, is expected to play a crucial role in guiding the company's financial direction as Karyopharm scales its operations toward increased revenue, particularly from XPOVIO.

Insights from the Leadership

Richard Paulson, the President and CEO of Karyopharm, expressed enthusiasm over Lori's appointment, stating, "Lori is an outstanding addition to the Karyopharm team. Her vast experience in strategic financial management and operations will be essential as we drive our initiatives forward to maximize the potential of XPOVIO while maintaining disciplined expense management."

A Proven Track Record

Lori Macomber brings over 20 years of versatile experience in financial leadership roles, demonstrating her capacity to drive growth and implement effective financial strategies across various life science companies. Her history of success spans from startups to Fortune 500 enterprises, marking her as a notable figure ready to elevate Karyopharm.

Previous Engagements and Expertise

Before joining Karyopharm, Lori served as CFO at Legend Biotech Corporation, enhancing her experience in managing the complexities of commercial-stage biopharmaceutical firms. Her professional journey includes significant leadership roles at Ametek PDS, Cello Health, Eli Lilly and Company, and Pfizer, equipping her with invaluable insights into operational efficiency and financial optimization. Additionally, Lori is a Certified Public Accountant, holding a Bachelor of Science in Accounting from Pennsylvania State University.

Inducement Awards Strategy

In connection with her new role, Karyopharm has awarded Lori inducement stock options and restricted stock units as part of her compensation package. This comprises a stock option to purchase 650,000 shares and 160,000 restricted stock units, granted under Karyopharm's 2022 Inducement Stock Incentive Plan. These incentives underscore the company’s commitment to rewarding dedication and aligning Lori's success with the company's future performance.

Vesting and Employment Terms

The granted stock options will vest over four years, while the restricted stock units will vest over three consecutive anniversaries. These types of compensation not only motivate but also ensure that key leadership remains committed to Karyopharm’s long-term strategy and objectives.

About Karyopharm Therapeutics

Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is dedicated to advancing unique cancer therapies. Since its establishment, the company has emerged as a frontrunner in developing oral drug candidates targeting nuclear export dysregulation, a key factor in oncogenesis. Its flagship product, XPOVIO (selinexor), has earned regulatory approval in the United States across three oncology indications and has expanded its reach to several international markets, exhibiting Karyopharm’s significant footprint in the healthcare sector.

Innovating Cancer Care

Karyopharm is committed to addressing substantial unmet medical needs with its expansive pipeline, which targets a variety of severe cancers, such as multiple myeloma and diffuse large B-cell lymphoma. This strategic direction not only aims to contribute positively to the patient community but also reinforces Karyopharm's position within the pharmaceutical industry.

Frequently Asked Questions

What is Karyopharm's main focus as a pharmaceutical company?

Karyopharm focuses on developing innovative cancer therapies, particularly targeting oncology through unique oral compounds.

Who is Lori Macomber, and what role will she play at Karyopharm?

Lori Macomber is the new Chief Financial Officer, bringing extensive financial expertise to guide the company's fiscal strategies and operations.

What is XPOVIO and its significance to Karyopharm?

XPOVIO (selinexor) is Karyopharm's lead product, an oral exportin 1 inhibitor approved in the U.S. for multiple oncology indications.

How will Lori's experience benefit Karyopharm?

Lori's diverse background in financial management will enable Karyopharm to optimize its growth and navigate the complexities of the pharmaceutical sector more effectively.

What future milestones can we expect from Karyopharm?

Karyopharm aims to expand its product pipeline and continue advancing its therapies in multiple high unmet need cancers.

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