iTeos Therapeutics Reveals Strategic Goals for Advancement

iTeos Therapeutics Unveils Ambitious Strategic Priorities

iTeos Therapeutics, Inc. (Nasdaq: ITOS), a pioneer in the development of immuno-oncology therapeutics, has recently announced its strategic goals for the upcoming year. This new roadmap outlines a series of clinical trials and program advancements that position the company for success in the oncology field. Their anticipated progress includes critical data readouts from a variety of clinical studies and a focus on innovative drug candidates.

Highlighted Clinical Programs and Research

The company is set to report multiple clinical data readouts throughout the year, which include evaluations involving over 400 patients. This substantial body of research will encompass two Phase 2 trials and one Phase 1/2 trial, assessing the combination of belrestotug and dostarlimab in first-line non-small cell lung cancer (NSCLC) and first-line head and neck squamous cell carcinoma (HNSCC). These trials underscore iTeos's commitment to tackling resistance within the tumor microenvironment, a critical challenge in the treatment of cancer.

Belrestotug Development

Belrestotug (EOS-448) is an IgG1 anti-TIGIT monoclonal antibody being investigated for treating patients with advanced stages of PD-L1-high NSCLC and recurrent/metastatic HNSCC. In collaboration with GSK, iTeos is developing this promising therapy. The ongoing Phase 3 GALAXIES Lung-301 study is a key component of this program, which has received FDA and NMPA approval to advance to the recommended Phase 3 dose.

Upcoming Data and Expectations

Interim data from the Phase 2 platform studies GALAXIES Lung-201 and GALAXIES H&N-202 are expected to be reported in 2025. These studies will assess the efficacy and safety of belrestotug combined with dostarlimab and GSK’s investigational anti-CD96 antibody, nelistotug, in a clinical cohort surpassing 240 patients. The data from these studies is critical as it will be submitted for presentation at a scientific congress later in the year.

Exciting Innovations: EOS-984 and EOS-215

In addition to belrestotug, iTeos is advancing other promising therapeutic candidates. EOS-984, a potential first-in-class small molecule targeting ENT1, aims to inhibit the immunosuppressive effects of adenosine, thereby rejuvenating T-cell responses in cancer therapies. Topline data assessing EOS-984, both as a monotherapy and in combination with pembrolizumab, is projected for release in the second half of the year.

Furthermore, EOS-215 represents a groundbreaking approach in targeting tumor-associated macrophages. This novel anti-TREM2 monoclonal antibody has the potential to reprogram the tumor microenvironment, enhancing anti-tumor immunity. The Investigative New Drug (IND) application for EOS-215 is scheduled for submission in the first quarter of 2025, opening up new avenues for treatment options.

Financial Position and Future Outlook

As of the end of September 2024, iTeos reported a robust cash balance of $683.9 million. This financial position is expected to support its operations and research initiatives through 2027, indicating a solid runway for the potential initiation of several Phase 3 registrational trials centered around the combination therapy of belrestotug and dostarlimab.

The Mission of iTeos Therapeutics

iTeos Therapeutics is dedicated to inventing and realizing the next generation of immuno-oncology therapies tailored for patients combating cancer. Equipped with extensive knowledge of tumor immunology, the company is positioned to formulate novel product candidates with distinct pharmacologic properties aimed at improving treatment outcomes. The pipeline is comprising three clinical-stage programs that specifically target validated immunosuppressive pathways, optimizing their potential effectiveness.

Frequently Asked Questions

What is iTeos Therapeutics planning for 2025?

The company has outlined strategic priorities, including multiple clinical trials and data readouts targeting advanced cancers.

What is belrestotug?

Belrestotug is an IgG1 anti-TIGIT monoclonal antibody aimed at treating advanced PD-L1-high NSCLC and HNSCC.

When will data from the clinical trials be reported?

Several clinical data readouts are anticipated throughout 2025, with pivotal interim data expected in the second quarter.

What other therapies is iTeos developing?

iTeos is also advancing EOS-984, which targets ENT1, and EOS-215, an anti-TREM2 monoclonal antibody.

What is the current financial status of iTeos Therapeutics?

The company holds a cash balance of $683.9 million, supporting its research and clinical initiatives through 2027.

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