IO Biotech Highlights Breakthrough Cancer Vaccine Presentations

IO Biotech Announces Significant Poster Presentations

IO Biotech (NASDAQ: IOBT), a pioneering clinical-stage biopharmaceutical company, is excited to share details about its two impactful abstracts that have been accepted for presentation at the upcoming Society for Immunotherapy of Cancer's (SITC) annual meeting. These presentations will showcase the latest advancements in developing the company’s immune-modulating therapeutic cancer vaccines based on their innovative T-win platform.

Overview of the Presentations

The first abstract highlights updated findings from a clinical trial involving patients diagnosed with PD-L1 high metastatic non-small cell lung cancer (NSCLC). Specifically, it presents data from the complete cohort in the first-line treatment setting of IO102-IO103 coupled with pembrolizumab—a well-known anti-PD-1 therapy by Merck. The insights from this trial aim to shed light on therapeutic benefits and the impact of this combination on patient outcomes.

Details on the First Presentation

Title: A Phase 2 Trial of the IO102-IO103 Vaccine Plus Pembrolizumab

Presenter: Dr. Jonathan W. Riess from UC Davis Comprehensive Cancer Center
Poster Presentation Number: 756
Date: Saturday, November 9
Location: George R. Brown Convention Center

This presentation will feature findings from a study with 31 patients, providing comprehensive data on the effectiveness and potential of the vaccine in combating aggressive NSCLC.

Second Abstract Focus

The second abstract introduces promising pre-clinical data for IO Biotech's next candidate, IO112, which specifically targets Arginase 1. This candidate represents another pivotal step in IO Biotech's commitment to developing groundbreaking therapies that can control tumor growth through immune modulation.

Details on the Second Presentation

Title: Immune Modulating Vaccine Against Arginase 1 Controls Tumor Growth

Presenters: Dr. Evelina Martinenaite and Dr. Inés Lecoq
Poster Presentation Number: 1038
Date: Saturday, November 9
Location: George R. Brown Convention Center

This session will delve into how targeting Arginase 1 can promote a favorable immune response, facilitating the body’s ability to fight against tumors.

What to Expect at the Convention

The presentations will take place over an extensive timeline, allowing for interactive discussions and networking opportunities. Both posters will be accessible throughout the conference, fostering engagements between researchers, clinicians, and attendees interested in the advancements in cancer immunotherapy.

About IO Biotech’s T-win Platform

IO Biotech is a clinical-stage company focused on developing transformative vaccines designed to override immune suppression mechanisms present in tumors. The T-win platform enhances T cell activation, ensuring an effective anti-tumor response. Ongoing studies, including a pivotal Phase 3 trial for IO102-IO103 in combination with pembrolizumab against advanced melanoma, highlight the company’s dedication to improving patient care.

IO102-IO103 has already shown considerable success, having received breakthrough therapy designation from regulatory authorities based on early clinical findings. Such recognition underscores the potential impact this therapy could have on patient survival and quality of life.

Final Remarks on IO Biotech

Headquartered in Copenhagen with a US office in New York, IO Biotech maintains a robust pipeline aimed at tackling some of the toughest challenges in oncology. As IO Biotech continues its journey through clinical trials and scientific exploration, it remains committed to innovating cancer therapies that empower the body’s immune system.

Frequently Asked Questions

What is the significance of IO Biotech's presentations at SITC?

The presentations provide an opportunity to share groundbreaking results and insights related to their cancer vaccine candidates, enhancing understanding and collaboration in the oncology community.

When will the presentations occur?

Both presentations are scheduled for Saturday, November 9, 2024, during the Society for Immunotherapy of Cancer’s annual meeting.

Who will be presenting at the event?

Dr. Jonathan W. Riess will present the first abstract and Dr. Evelina Martinenaite along with Dr. Inés Lecoq will present the second abstract.

What is IO Biotech's T-win platform?

The T-win platform is a unique approach to cancer vaccines aimed at activating T cells to target immunosuppressive cells within tumors, thereby enhancing tumor suppression.

How can one learn more about IO Biotech?

Additional information can be found by visiting IO Biotech’s official website or connecting through their social media channels.

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