Innovent and Lilly Enhance Cancer Treatment Access Across China

Innovent and Lilly's Collaboration on Jaypirca®

Innovent Biologics, Inc. (HKEX: 01801), noted for its commitment to developing high-quality medicines, has formed a significant partnership with Eli Lilly and Company (NYSE: LLY) to expand the commercialization of Jaypirca® (pirtobrutinib) in China. This collaboration is especially significant as Jaypirca® represents a breakthrough in treating patients with mantle cell lymphoma who have previously been treated with other Bruton's tyrosine kinase (BTK) inhibitors.

Responsibilities Under the New Agreement

As part of the distribution and promotion agreement, Innovent will manage the importation, marketing, and distribution of Jaypirca®. On the other hand, Lilly will focus on research and development alongside post-market medical affairs for the product. This strategic division of responsibilities has been crafted to leverage both companies' strengths, ensuring that patients can rapidly access this innovative therapy.

Significance of Jaypirca®

Jaypirca® operates through a unique non-covalent binding mechanism, making it the only non-covalent BTK inhibitor approved by the U.S. FDA in early 2023. Jaypirca® is intended for adult patients with relapsed or refractory mantle cell lymphoma, extending treatment options for individuals who have exhausted other therapies. In October 2024, the product garnered approval from China's National Medical Products Administration (NMPA) as a monotherapy for those who have not responded adequate to previous treatments.

Focus on Clinical Development

Alongside the agreement, Lilly is actively conducting global Phase 3 clinical trials to evaluate the efficacy of Jaypirca® in patients with chronic lymphocytic leukemia and BTK inhibitor-naïve mantle cell lymphoma. This research is crucial, as it aims to explore both monotherapy and combination therapy for patients who have limited options available.

Innovent's Commitment to Oncology

Leading the commercialization of Jaypirca® in China, Innovent is tapping into its strong commercial teams to ensure the drug reaches patients effectively. Dr. Michael Yu, the Founder and CEO of Innovent, emphasized the company's dedication to making high-quality medicines more accessible and enhancing treatment outcomes for cancer patients.

The Future of Cancer Treatment in China

The partnership not only underscores Innovent's ambitions in the oncology arena but also symbolizes a broader commitment to addressing healthcare needs in China. By improving treatment accessibility and outcomes, this collaboration plays an essential role in enhancing the overall landscape of health care in the region.

About Jaypirca® (pirtobrutinib)

Jaypirca® is recognized for its selective action, targeting BTK—an enzyme linked to various B-cell malignancies. This non-covalent, reversible inhibitor represents a hopeful option for patients who have previously utilized other BTK therapies. The significance of Jaypirca® goes beyond mere numbers—it represents a transformative step for individuals grappling with difficult-to-treat cancers.

Innovent Biologics and Its Mission

Founded in 2011, Innovent seeks to provide affordable, innovative medications that address serious health challenges. The company has launched numerous products and maintains a pipeline of therapies aimed at critical diseases, reinforcing its status as an influential player in biopharmaceutical development.

Innovative Collaborations in Medicine

Innovent and Lilly have crafted an impactful partnership that balances collaborative efforts in research and commercialization. Their continuous joint initiatives since 2015 have fostered improvements in oncology treatment options, effectively addressing a crucial need within the healthcare system. The success of this partnership is defined by their unwavering commitment to prioritize patients and innovate their therapeutic approaches.

Frequently Asked Questions

1. What is Jaypirca® used for?

Jaypirca® is a non-covalent BTK inhibitor indicated for treating adult patients with relapsed or refractory mantle cell lymphoma.

2. Who is responsible for the marketing of Jaypirca® in China?

Innovent Biologics holds the sole commercialization rights and is responsible for the marketing, distribution, and promotion of Jaypirca® in China.

3. How does Jaypirca® work?

Jaypirca® works by inhibiting BTK through a reversible non-covalent binding mechanism, thus managing cancer cells more effectively.

4. What other partnerships does Innovent have?

Innovent partners with over 30 international healthcare companies, including Eli Lilly, to develop and provide innovative therapies.

5. What is the goal of Innovent's collaborations?

The primary goal is to improve patient access to innovative therapies and enhance treatment outcomes throughout the regions they serve.

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