Innovative T-Cell Cancer Treatment Shows Promise with SLS009
SELLAS Life Sciences Unveils Promising Preclinical Results
SELLAS Life Sciences Group, Inc. (NASDAQ: SLS) is making strides in the fight against cancer with its development of SLS009, a highly selective CDK9 inhibitor. Recent preclinical studies on SLS009 show significant survival benefits for patients with T-cell prolymphocytic leukemia (T-PLL), paving the way for new treatment options where few exist. The findings will be showcased at the European Society for Medical Oncology Congress.
Preclinical Study Highlights
The study focuses on an in vivo patient-derived xenograft (PDX) model specifically designed for relapsed or refractory T-PLL. This model closely mirrors the human condition, showcasing the efficacy of SLS009 as both a standalone treatment and in combination with venetoclax. The results reveal that SLS009 dramatically improved survival intervals—7.4 weeks for the monotherapy and 7.9 weeks when paired with venetoclax—surpassing the 4.4 weeks observed with venetoclax alone.
Significance of the Findings
Analysis indicates that the combination of SLS009 and venetoclax not only prolonged survival but also maintained better control of circulating T-PLL cells compared to other treatments, emphasizing its potential to become a vital resource for managing aggressive leukemia.
Expert Insights on SLS009
According to Dr. Dragan Cicic, Senior Vice President and Chief Development Officer at SELLAS, these promising preclinical results provide key evidence regarding the role of selective CDK9 inhibition in treating aggressive forms of leukemia. He highlights that SLS009 displays a promising profile not just for T-PLL, but also for broader applications in hematologic malignancies.
Development of an Advanced Model
Dr. Francisco Vega from the University of Texas MD Anderson Cancer Center notes the significance of their developed PDX model. By effectively replicating the human condition, this model allows for faster transitions from laboratory studies to clinical applications. It greatly enhances the pace of drug development, enabling more efficient assessment of potential treatments like SLS009.
Upcoming Presentation Details
SLS009 will be presented at an upcoming poster session at the European Society for Medical Oncology Congress:
Title: CDK9 Inhibition Enhances Venetoclax Activity and Prolongs Survival in a T-PLL Patient-Derived Xenograft Model
Session Date and Time: The presentation is scheduled for Saturday, 12:00 PM to 12:45 PM CEST, with the poster available for viewing from 9:00 AM to 5:00 PM CEST.
About SELLAS Life Sciences Group
SELLAS Life Sciences is dedicated to developing cutting-edge therapeutics targeting various cancer types. With their lead product candidate GPS aimed at the WT1 protein found in many tumor types, SELLAS shows promise in addressing a wide range of hematologic malignancies and solid tumors. Alongside SLS009, the company’s portfolio showcases their commitment to innovation and patient care in the oncology landscape.
Frequently Asked Questions
What is SLS009?
SLS009, or tambiciclib, is a novel CDK9 inhibitor developed by SELLAS Life Sciences, showing promise in treating T-cell prolymphocytic leukemia.
What were the notable outcomes from the preclinical study?
The preclinical study reported significant survival improvements with SLS009, with survival times of 7.4 weeks in monotherapy and 7.9 weeks in combination with venetoclax.
Who led the study on SLS009?
The study was led by Dr. Francisco Vega from the University of Texas MD Anderson Cancer Center, an expert in hematopathology.
Why is the PDX model important?
The PDX model developed in this study closely mirrors the disease's behavior in humans, facilitating faster and more reliable data translation to clinical settings.
How does SELLAS contribute to cancer treatment advancements?
SELLAS is focused on developing innovative therapies for various cancers, aiming to provide new options where treatment is limited, improving patient outcomes significantly.
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