Innovative Retinal Treatments at Clinical Trials Meeting

Revolutionizing Retinal Therapy Delivery

Clearside Biomedical, Inc. (Nasdaq: CLSD) is setting a new standard in the treatment of retinal diseases through its innovative suprachoroidal space (SCS) injection technology. The company recently announced multiple presentations at a prominent meeting highlighting its advancements in retinal care.

Insights from the Clinical Trials at the Summit

At this influential gathering, Clearside's advancements in therapy delivery will be highlighted, demonstrating the efficacy of its proprietary SCS Microinjector platform. This method provides a revolutionary in-office solution for administering therapies aimed at preserving vision for patients suffering from various retinal conditions. The flexibility of this system allows for the delivery of multiple treatment modalities, a commitment that reflects Clearside’s focus on redefining patient care in the ophthalmic space.

Expert Commentary from Leadership

Victor Chong, MD, MBA, Chief Medical Officer and Executive Vice President at Clearside, remarked, "Our SCS Microinjector represents a significant innovation in how therapies reach the back of the eye. With a robust clinical pipeline, we see our delivery platform supporting diverse therapeutic strategies that offer sustained outcomes and flexible dosing options for complex retinal diseases."

Highlighted Presentations from Clearside and Partners

Several notable presentations at the meeting will focus on Clearside and its partnerships:

• Suprachoroidal CLS-AX for nAMD: Phase 3 Program Update
  Presented by: Sobha Sivaprasad, MD, an expert in retinal clinical research from Moorfields Eye Hospital, UK.
• Partner: REGENXBIO
  Update on One-Time Suprachoroidal ABBV-RGX-314 for the Treatment of Diabetic Retinopathy
  Presented by: Anna Abolian, OD, Senior Medical Director at REGENXBIO Inc.
• Partner: Aura Biosciences
  Bel-sar - a New Treatment Paradigm in Choroidal Melanoma: Update on the Global Phase 3 CoMpass Trial
  Presented by: Jennifer Lim, MD, at the University of Illinois School of Medicine.

Understanding CLS-AX

Among Clearside's promising therapies is CLS-AX, an injectable suspension designed for sustained action against retinal ailments. This unique formulation features the tyrosine kinase inhibitor axitinib, known for its potency in inhibiting key VEGF receptors associated with angiogenesis. Current oral formulations are available for other conditions, but the suprachoroidal route enhances drug delivery specifically to the affected areas, minimizing exposure to unaffected tissues.

Clinical Trial Highlights for CLS-AX

Preliminary results from Phase 1/2a and Phase 2b clinical trials indicate that CLS-AX not only achieves significant therapeutic outcomes but is also well-tolerated, paving the way for further development aimed at conditions like wet age-related macular degeneration (AMD).

The SCS Injection Platform: Pioneering Eye Therapy

Clearside’s proprietary SCS injection platform allows for unprecedented access to the back of the eye, targeting sight-threatening diseases effectively. This platform’s flexibility means it can adapt to various drug formulations, potentially increasing their efficacy. The SCS Microinjector device is a key innovation for delivering medication directly where it is needed, using a unique syringe with customizable microneedle lengths to ensure precise compartmental delivery of therapies.

Company Overview and Strategic Vision

Clearside Biomedical, Inc. is committed to transforming the treatment landscape for retinal diseases through its innovative approaches. With a multitude of development programs underway, including small molecule candidates tailored for the SCS Microinjector, the company aims to improve the lives of patients battling significant visual impairments. Their lead program, CLS-AX, is positioned as a front-runner in the treatment of wet AMD with a Phase 3 program actively in the works.

Frequently Asked Questions

What is the significance of the CLS-AX product?

CLS-AX represents a significant innovation in the treatment of retinal diseases, utilizing a unique axitinib formulation delivered via suprachoroidal injection for improved potency and targeted effects.

How does Clearside's microinjector enhance therapy delivery?

The SCS Microinjector allows for targeted delivery of therapies directly to the back of the eye, which can enhance the effectiveness of treatments while minimizing potential side effects.

What diseases are being targeted by Clearside's therapies?

Clearside is focused on retinal diseases, specifically conditions like wet AMD and diabetic retinopathy, which pose a significant risk to vision.

Who are Clearside's partners in research?

Clearside collaborates with several reputable partners, including REGENXBIO and Aura Biosciences, to advance the research and development of new therapies.

How can I get more information about Clearside Biomedical?

For more details about Clearside's projects and innovations, visit their official website or their social media profiles.

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