Innovative Cytokine Solution Revolutionizes CAR-T Therapy Production

Transforming CAR-T Therapy Production with New Cytokine Solution

In an exciting development for cell and gene-modified cell therapy, ScaleReady and Bio-Techne Corporation (NASDAQ: TECH) introduced the G-Rex optimized ProPak GMP Cytokines. This innovative product is specifically designed for high-efficiency closed system manufacturing, transforming the production landscape for CAR-T and TCR therapies.

The ProPak GMP Cytokines feature a ready-to-use, weldable bag that contains liquid GMP-grade cytokines. These cytokines, notably interleukin-7 (IL-7) and interleukin-15 (IL-15), play a crucial role in the ex vivo culture of CAR-T and TCR-T cells. Each ProPak is formulated to provide enough cytokine dosage for a one-liter G-Rex bioreactor at a precise concentration of 10ng/mL, streamlining operational complexity in therapy production.

Benefits of ProPak GMP Cytokines

The introduction of ProPak GMP Cytokines signifies a major advancement in how manufacturers handle critical reagents in cell therapy production. With the use of these cytokines, companies can significantly cut costs and simplify their workflows. The new packaging eliminates the burdensome steps of acquiring, storing, and preparing cytokines, enabling a more streamlined manufacturing process that meets cGMP standards.

Expert Insights on the New Product

According to Will Geist, President of Protein Sciences at Bio-Techne Corporation, the organization is dedicated to enhancing the manufacturing of life-saving therapies. He emphasized that ProPak Cytokines were crafted for optimal use with the leading G-Rex platform, which contributes to improved outcomes in the production of cell-based drugs.

Similarly, Josh Ludwig, the Global Commercial Director at ScaleReady, noted that this product stands out as it significantly simplifies the manufacturing process. Users can produce CAR-T and TCR-T therapies without the agonies of cytokine reconstitution, opting instead for a user-friendly approach that captures the benefits of the G-Rex manufacturing suite.

Widespread Adoption and Support

This innovative approach has been pivotal in the G-Rex Grant Program, which is designed to promote the use of the G-Rex platform in clinical trials. With many organizations already utilizing the G-Rex system, the ProPak GMP Cytokines are now placed to enhance productivity further. Ludwig reassured that all G-Rex users, whether they apply for grants or not, can effectively leverage the ProPak for their comparability studies.

About ScaleReady

ScaleReady dedicates itself to providing the cell and gene-modified cell therapy sector with a G-Rex centric manufacturing platform. This commitment enables the development and manufacturing of CGT products that are scalable and economical. Companies leveraging ScaleReady's comprehensive expertise can expect to mitigate lengthy timelines and financial burdens associated with entering the CGT market.

Utilizing the G-Rex Manufacturing Platform

The G-Rex platform has already been employed in half of all clinical trials and serves over 800 organizations involved in producing CGT drugs. The system's flexibility and reliability have led to the commercial approval of four CGT drugs, showcasing its benefits in both autologous and allogeneic therapies. The future looks promising as ScaleReady continues to expand its impact within the CGT field.

About Bio-Techne Corporation

Bio-Techne Corporation (NASDAQ: TECH) is recognized as a leader in the life sciences sector, supplying groundbreaking tools and bioactive reagents that facilitate research and clinical diagnostics. The company collaborates with Wilson Wolf to develop specialized media and cytokines that align perfectly with G-Rex Bioreactors, ensuring optimal performance in high throughput manufacturing.

Frequently Asked Questions

What are ProPak GMP Cytokines?

ProPak GMP Cytokines are a new product designed for closed system manufacturing of CAR-T and TCR therapies, featuring a ready-to-use format with GMP-grade cytokines.

How do ProPak GMP Cytokines benefit therapy production?

The ProPak simplifies the acquisition and handling of cytokines, reduces operational costs, and ensures compliance with manufacturing regulations.

What cytokines are included in the ProPak?

Each ProPak is formulated with interleukin-7 (IL-7) and interleukin-15 (IL-15), essential for the effective culture of CAR-T and TCR-T cells.

Can users of G-Rex access the ProPak Cytokines?

Yes, G-Rex users, including those who do not apply for grants, can utilize ProPak GMP Cytokines for their compatibility studies and production needs.

What is the G-Rex Grant Program?

The G-Rex Grant Program supports organizations using the G-Rex platform, helping them integrate new technologies like ProPak GMP Cytokines into their operations.

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