Innovative B Cell Treatment CLN-978 Shows Promising Data

Cullinan Therapeutics Advances Innovative Autoimmune Treatment

Cullinan Therapeutics, Inc. (NASDAQ: CGEM) has unveiled promising new preclinical findings for CLN-978, their advanced CD19xCD3 bispecific T cell engager. This innovative treatment targets B cells in various autoimmune diseases, showing significant potential for clinical application.

Significant Preclinical Data Presentation

The latest data will be highlighted at the ACR Convergence 2025, taking place in Chicago. The presentation is set for a poster session on October 28, where Cullinan will share insights from their extensive research.

How CLN-978 Works

CLN-978 exhibits a remarkable capability to deplete target B cells while activating T cells from human peripheral blood mononuclear cells. This was observed in patients with conditions such as rheumatoid arthritis, Sjögren's disease, and lupus, demonstrating the drug's effectiveness compared to healthy controls.

Promising Results in Nonhuman Primates

In studies involving nonhuman primates, subcutaneous administration of CLN-978 resulted in dose-dependent B cell depletion. The data suggests that doses tolerated by the primates achieved profound depletion in various tissues, including bone marrow and lymph nodes.

Impact in Murine Models

Research using murine models for systemic lupus erythematosus indicated that treatment with CLN-978 led to a decrease in circulating B cells as well as lower levels of markers associated with disease activity. These findings suggest a potential for CLN-978 to modify the underlying diseases, offering more than just symptomatic relief.

Expert Insights on Clinical Implications

Dr. Jeffrey Jones, Chief Medical Officer of Cullinan Therapeutics, expressed optimism about CLN-978's potential, stating, "Our ongoing preclinical studies reassert the promise of CLN-978 as a T cell engager capable of deeply depleting B cells in autoimmune settings." Dr. Jones emphasizes the need for therapies that address the root causes of these challenging conditions.

Global Clinical Development of CLN-978

Cullinan is actively advancing global clinical trials for CLN-978, particularly focusing on autoimmune diseases. The OUTRACE studies encompass multiple indications, including rheumatoid arthritis, Sjögren's disease, and systemic lupus erythematosus, with trials launched across various countries.

About CLN-978

CLN-978 is noted for its novel mechanism as a CD19xCD3 bispecific T cell engager, specifically designed for targeting B cells. The treatment’s molecular design promises an effective approach for patients, especially with its ability to recommend subcutaneous delivery, which could enhance patient convenience.

About Cullinan Therapeutics

Cullinan Therapeutics, Inc. focuses on innovative analytical techniques aimed at discovering impactful therapies for autoimmune issues and cancer treatments. The company's structured pipeline is driven by thorough scientific research and innovative strategies, highlighting their commitment to improving patient care.

Frequently Asked Questions

What is CLN-978?

CLN-978 is a CD19xCD3 bispecific T cell engager designed to selectively target and eliminate B cells in autoimmune diseases.

Where will the new data be presented?

The new preclinical findings for CLN-978 will be presented at the ACR Convergence 2025 in Chicago.

What diseases are being targeted by CLN-978?

CLN-978 is being tested for efficacy in treating rheumatoid arthritis, Sjögren's disease, and systemic lupus erythematosus.

How does CLN-978 work?

CLN-978 works by binding to CD19 on B cells and CD3 on T cells, directing the immune response to effectively deplete B cells.

Who is leading the research on CLN-978?

The research is led by the team at Cullinan Therapeutics, guided by Dr. Jeffrey Jones, the Chief Medical Officer.

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