ImmunoScape Receives G-Rex Grant to Advance TCR-T Therapies

ImmunoScape Receives G-Rex Grant to Advance TCR-T Therapies

In an exciting development for immunotherapy, ImmunoScape Pte. Ltd., a pioneer in TCR-T cell therapy, has been awarded the G-Rex Grant, a supportive initiative created by ScaleReady alongside Wilson Wolf Manufacturing and Bio-Techne Corporation (NASDAQ: TECH). This grant of $250,000 is poised to significantly enhance the process development and IND enabling studies for ImmunoScape's innovative WT1-targeted TCR-T cell therapy.

Significance of the G-Rex Grant

This funding is expected to make a substantial impact on ImmunoScape's efforts to bring their groundbreaking therapy closer to clinical applications. Dr. Tania Ribeiro, Senior Director and Head of CMC, expressed gratitude for the G-Rex Grant Program, emphasizing its role in easing the time and costs associated with clinical readiness.

Advancing Clinical Objectives

John Wilson, CEO of Wilson Wolf and co-inventor of the G-Rex technology, highlighted the program's objective to expedite ImmunoScape's journey toward generating robust clinical data that investors seek. By leveraging the G-Rex technology and the support provided through this grant, ImmunoScape is set to make significant strides in developing their TCR-T cell therapy.

Enhancing Manufacturing Processes with G-Rex

Part of the G-Rex Grant will enable ImmunoScape to integrate Wilson Wolf's state-of-the-art G-Rex bioreactors into their preclinical development processes. The new ProPak™ GMP Cytokines produced by Bio-Techne, specifically designed for G-Rex, will streamline the preparation and administration of crucial reagents in a GMP environment. This collaboration is anticipated to minimize costs and simplify production, enabling savings that can exceed thousands of dollars with each manufacturing run.

Producing Quality IND Data

The G-Rex Grant will also facilitate the technology transfer of ImmunoScape's unique manufacturing process to its Contract Development and Manufacturing Organization (CDMO) partner. The support will encompass training and engineering runs critical for compiling the necessary manufacturing batch records, an essential step for their IND submission to the FDA projected for a future date.

ScaleReady's Pioneering Role in Gene Therapy

ScaleReady's G-Rex Grant Program is a robust $20 million initiative designed to advance the development and manufacturing of cell and gene-modified cell therapies (CGT). With grant awards reaching up to $300,000, recipients gain access to an invaluable consortium of partners offering cutting-edge tools, technologies, and substantial expertise in areas such as cGMP manufacturing and regulatory affairs, amongst others.

Supporting Next-Gen Cancer Treatments

ImmunoScape's commitment to developing next-generation TCR-T cell therapies places it at the forefront of innovative cancer treatment solutions. The company's approach combines Deep Immunomics with AI-driven insights to identify TCRs presenting superior therapeutic potential. With ongoing programs in the discovery phase and preparing for clinical development, ImmunoScape is determined to bring transformative therapies to the market.

Why G-Rex Matters in CGT Development

The G-Rex manufacturing platform is utilized by over 800 organizations, being instrumental in approximately 50% of ongoing CGT clinical trials, along with contributing to marketed CGT therapies. ScaleReady's expertise allows CGT entities to save valuable time and financial resources, propelling them closer to successful commercialization of their therapies. With entities like Bio-Techne and Wilson Wolf collaborating, the prospects for innovative breakthroughs in treatment methodologies remain promising.

Frequently Asked Questions

What is the G-Rex Grant and who benefits from it?

The G-Rex Grant is a funding initiative by ScaleReady aimed at supporting the development of cell and gene-modified therapies, benefiting organizations like ImmunoScape.

How will ImmunoScape utilize the grant funds?

The funds will aid in developing IND-enabling studies and enhancing their manufacturing processes, including access to advanced bioreactors and cytokines.

Why is the G-Rex technology important?

G-Rex technology provides scalable and efficient manufacturing solutions for cell therapies, thus reducing costs and improving production reliability.

What types of therapies is ImmunoScape focusing on?

ImmunoScape is developing TCR-T cell therapies specifically targeted for solid tumors, utilizing cutting-edge approaches grounded in Deep Immunomics.

How does ScaleReady contribute to the future of CGT?

ScaleReady's resources and partnerships empower organizations working in gene therapy to expedite their development processes, enhancing therapeutic innovation.

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