Hubble Therapeutics Secures Series A Funding for Gene Therapy
Hubble Therapeutics Closes Series A Funding Round
Hubble Therapeutics LLC, a pioneering biotechnology company dedicated to combating pediatric blindness, has made headlines with the successful closing of a $7.3 million Series A funding round. This significant boost will enable the company to advance its lead gene therapy candidate, HUB-101, towards crucial human clinical trials, marking a major step in their mission to develop effective treatments for children facing severe vision loss.
Understanding the Impact of LCA16 and SVD
The gene therapy Hub-101 specifically targets two extremely rare and debilitating eye disorders: Leber Congenital Amaurosis Type 16 (LCA16) and Snowflake Vitreoretinal Degeneration (SVD). These conditions are linked to mutations in the KCNJ13 gene, an essential component for the function of ion channels found in the retina’s pigment epithelium. Affected children often exhibit symptoms before the age of five, which lead to gradual retinal degeneration and ultimately, blindness.
Expert Insights on Gene Therapy Development
Dr. Bikash Pattnaik, an esteemed professor at the University of Wisconsin-Madison and a scientific co-founder of Hubble Therapeutics, spoke passionately about the advancements in curative gene therapies for inherited blindness. "The HUB-101 gene therapy for LCA16 not only represents a scientific breakthrough but also promises hope for families devastated by hereditary vision loss. Our goal is to push the boundaries of current therapeutic methods, offering innovative solutions for genetic diseases at their roots," he shared.
Partnerships to Propel Development Forward
To ensure the success of the HUB-101 program, Hubble Therapeutics has established partnerships with Andelyn Biosciences and Virscio. These collaborations are aimed at aiding in the development and manufacturing processes, as well as conducting essential IND-enabling studies to ensure the therapy's safety and efficacy. With these partnerships, Hubble Therapeutics is gearing up to enter the clinic in 2026, where they anticipate beginning Phase I/II clinical trials.
The Importance of Investment in Medical Research
Greg Keenan, Senior Director of WARF Ventures & Accelerator, expressed optimism regarding the research conducted at Hubble Therapeutics. "Our investment as the co-lead investor in this Series A round underscores our commitment to supporting innovative research aimed at altering the course of rare diseases. The collaboration between Hubble Therapeutics and Dr. Pattnaik epitomizes the transformative power of academic-industry joint efforts, and we're excited to witness the progress this research will bring," he stated.
Commitment to Patient-Centric Approaches
Jeff Sabados, the Founder and President of Hubble Therapeutics, emphasized the importance of their partnerships and investor relationships. He acknowledged the dedication of scientists, industry experts, and patient families, stating, "With our newly secured funding and robust partnerships, we are determined to enhance HUB-101's manufacturing capabilities and drive the necessary studies that will take us to the clinic. Our unwavering promise is to support families impacted by LCA16 and SVD and work towards restoring vision for affected individuals."
About Hubble Therapeutics
Hubble Therapeutics LLC, often referred to as HubbleTx, is firmly committed to its mission of developing gene therapies with a focus on pediatric eye diseases. Utilizing pioneering research from Professor Bikash Pattnaik’s lab at the University of Wisconsin-Madison, the company aims to address the genetic mutations causing severe vision loss in conditions like LCA16 and SVD. Their dedication to rigorous clinical development ensures that the therapies they offer are not only effective but also accessible to those in need. By fostering collaboration and innovation, HubbleTx strives to illuminate a hopeful path forward for patients battling these life-altering conditions.
Frequently Asked Questions
What is HUB-101?
HUB-101 is a gene therapy designed to treat Leber Congenital Amaurosis Type 16 and Snowflake Vitreoretinal Degeneration, two severe eye disorders affecting children.
How much funding did Hubble Therapeutics secure?
Hubble Therapeutics successfully closed a $7.3 million Series A funding round to advance their research and clinical trials.
Who is leading the research for HUB-101?
The research for HUB-101 is led by Dr. Bikash Pattnaik at the University of Wisconsin-Madison, who has a vast experience in developing gene therapies for pediatric blindness.
When does Hubble Therapeutics plan to start clinical trials?
Hubble Therapeutics expects to begin Phase I/II clinical trials for HUB-101 in 2026.
What is the goal of Hubble Therapeutics?
The primary goal of Hubble Therapeutics is to develop innovative gene therapies that restore vision in patients suffering from genetic eye diseases.
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