Genespire Welcomes New Leadership with CEO Karen Aiach-Pignet

Genespire Welcomes New Leadership with CEO Karen Aiach-Pignet

Genespire is excited to announce the appointment of Karen Aiach-Pignet as the new Chief Executive Officer. This strategic decision reinforces Genespire's commitment to being at the forefront of in-vivo lentiviral gene therapy, specifically tailored for pediatric patients grappling with genetic disorders.

The Significance of Karen's Appointment

With a remarkable history in gene therapy, Karen brings a wealth of expertise to her new role. Previously, she founded and led Lysogene, a trailblazer in the industry. Her leadership helped advance an adeno-associated virus (AAV) vector therapy aimed at treating patients with Sanfilippo Type A, a rare neurodegenerative disease. She successfully initiated an international Phase 3 clinical trial and established partnerships that strengthened Lysogene's position on the Euronext Stock Exchange.

Focus on Advancing GENE202

Karen joins Genespire at a pivotal time as the company prepares to launch its lead candidate, GENE202, which aims to address methylmalonic acidemia (MMA). This troubling genetic disorder disrupts the metabolism of amino acids and fats, typically presenting at infancy with serious health implications. Currently, there are no disease-modifying options available, making Genespire's innovative approach incredibly critical.

Vision and Commitment

In her own words, Karen expressed her determination to enhance the lives of patients dealing with metabolic diseases. She stated, "Leading Genespire with the mission of creating safe and effective therapies for those in need is an immense privilege. I am committed to leveraging our unique ISLV technology, along with our dedicated team and investors, to propel this company towards success."

Acknowledging Past Leadership

Joern Aldag, Chairman of Genespire, also reflected on the transition, expressing gratitude to Dr. Julia Berretta, the former CEO, for her leadership over the past several years. He acknowledged the remarkable achievements of the Genespire team and emphasized the importance of Karen’s extensive experience in the fast-paced world of gene therapies, particularly for rare diseases and pediatric patients.

Karen’s Accomplishments and Background

Karen's career is marked by noteworthy contributions to the field of gene therapy. A founding member of the International Rare Diseases Research Consortium, she has participated as a member of the Pediatric Committee at the European Medicines Agency and served on the French Ethical Review Board. Additionally, she has contributed to multiple non-profit organizations focused on advocacy and research for rare diseases, validating her dedication to the community.

Educational Foundation

With a recent focus on Digital Health at Harvard Business School, Karen's educational background includes a degree from ESSEC Business School and an Economics major from the Institut d’Études Européennes at University Paris 8. This blend of practical experience and academic excellence positions her perfectly to lead Genespire into a new era of innovation.

About Genespire

Founded in 2020, Genespire is dedicated to developing off-the-shelf gene therapies that utilize immune shielded lentiviral vectors (ISLVs) designed for intravenous administration. This technology promises a long-lasting therapeutic effect directly from the patient's liver, and the company is initially focusing on inherited metabolic disorders with pressing medical needs. Based in Milan, Italy, Genespire is a spin-off from SR-Tiget, a renowned research institute specializing in cell and gene therapy.

Frequently Asked Questions

What position has Karen Aiach-Pignet been appointed to at Genespire?

Karen Aiach-Pignet has been appointed as the Chief Executive Officer at Genespire.

What is Genespire's focus area in biotechnology?

Genespire is focused on developing off-the-shelf gene therapies, particularly for pediatric patients with genetic diseases using immune shielded lentiviral vectors.

What is GENE202 aimed at treating?

GENE202 is targeted for the treatment of methylmalonic acidemia (MMA), a severe genetic disorder affecting metabolism.

What background does Karen Aiach-Pignet have in gene therapy?

Karen has extensive experience in gene therapy, previously founding and leading Lysogene, and has a track record of pioneering treatments for rare diseases.

Where is Genespire located?

Genespire is based in Milan, Italy, and operates as a spin-out from the SR-Tiget research institute.

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