Exploring the Advanced Endotrophin Assay by Nordic Bioscience
Nordic Bioscience Unveils the Advanced Endotrophin Assay
Nordic Bioscience has introduced the nordicEndotrophin™, an advanced automated high-precision assay designed to precisely quantify the intact 77-amino-acid Endotrophin signaling hormone. This assay has been validated in a laboratory that meets CAP/CLIA certification standards. The incorporation of nordicEndotrophin™ into the company's existing product lineup enhances the prognostic capabilities in the fields of fibrosis and cancer studies, creating a comprehensive care solution.
Revolutionizing Chronic Disease Assessments
NordicEndotrophin™ becomes a vital addition alongside existing biomarkers like nordicPRO-C6™ and nordicPRO-C3™, which are the in-house versions of recognized assays. This innovative assay offers an integrated approach to evaluate the fibro-inflammatory axis prevalent in chronic diseases such as cardiovascular and metabolic conditions. Following the recent integration of PRO-C3 into Roche IVD platforms, the new Endotrophin assay notably strengthens risk assessment and pharmacodynamic monitoring.
The Significance of Endotrophin in Health
Discovered as a collagen-derived hormone in 2012, Endotrophin is released from type VI collagen, which plays a significant role in activating fibroblasts and driving fibrosis in various organs. This process is fundamental to approximately 40% of mortality rates in Western countries. The hormone's expression is exacerbated in conditions like obesity, causing increased activation of fibroblasts in critical organs such as the liver, kidney, and heart. Notably, a two-fold increase in circulating Endotrophin levels has been linked to a 100% rise in mortality risk across chronic diseases.
A Deeper Understanding of Risk Stratification
Unlike the PRO-C6 assay, which measures the total pool of type VI collagen, nordicEndotrophin™ specifically zeroes in on the intact hormone, making it a powerful tool for additional risk stratification and providing complementary prognostic value. This distinct focus enhances the pharmacodynamic insights provided by the PRO-C6 assay, leading to better health outcomes and precise care.
Expert Insight on Endotrophin's Impact
Dr. Morten Karsdal, the CEO of Nordic Bioscience, commented, "Endotrophin is a crucial prognostic biomarker that has shown remarkable efficacy. In studies involving patients with HFpEF, both Endotrophin and PRO-C6 surpassed NT-proBNP concerning mortality and hospitalization risks. The ability to measure this important inflammatory hormone will significantly improve patient stratification and treatment monitoring across various conditions, including obesity and fibrotic diseases."
Advanced Assay Offerings
Available through Nordic Bioscience's CAP/CLIA-certified laboratory, the high-precision sandwich assay operates on fully automated and high-throughput platforms, ensuring top-tier accuracy. Clients utilizing nordicEndotrophin™ are encouraged to consider simultaneous measurements of nordicPRO-C3™ and nordicPRO-C6™. These assays collectively streamline the processes of risk stratification, patient enrichment, and proof-of-mechanism in anti-fibrotic and oncology trials.
About Nordic Bioscience
Nordic Bioscience stands as a pioneering company in biomarker development, rooted in its headquarters at Herlev, Denmark. The company dedicates itself to advancing biomarker technology through its specialized neoepitope technology. By integrating expertise in biomarker research with clinical and preclinical insights, Nordic Bioscience is committed to enhancing the speed and objectivity of decision-making during clinical trials. This initiative also aims to deliver significant diagnostic value to patients, ensuring improved treatment pathways.
Frequently Asked Questions
What is the nordicEndotrophin™ assay?
The nordicEndotrophin™ assay is a high-precision biomarker test that quantifies the signaling hormone Endotrophin, aiding in the prognosis of chronic diseases.
How does Endotrophin contribute to health assessments?
Endotrophin's levels can indicate the risk of fibrosis and chronic diseases, making it a vital marker in health assessments and treatment monitoring.
Where is the nordicEndotrophin™ test available?
The test is offered at Nordic Bioscience's CAP/CLIA-certified laboratory located in Herlev, Denmark.
How does the new assay integrate with existing products?
The assay complements existing products like nordicPRO-C3™ and nordicPRO-C6™, enhancing the assessment of the fibro-inflammatory axis in various conditions.
Why is Endotrophin significant?
Endotrophin serves as a critical biomarker linked to collagen progression and mortality risk, making its measurement important for precision medicine approaches.
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