Exploring Advances in Suprachoroidal Delivery by Clearside

Clearside Biomedical Highlights Suprachoroidal Delivery Innovations

Clearside Biomedical, Inc. (NASDAQ: CLSD), a pioneering biopharmaceutical company, has made significant strides in enhancing therapy delivery to the back of the eye through its innovative suprachoroidal space (SCS) technology. Recently, the company announced extensive participation in prominent ophthalmic medical conferences, where they are set to showcase groundbreaking advancements and analytical findings regarding their CLS-AX program, aimed at treating neovascular age-related macular degeneration (wet AMD).

Showcasing Achievements and Expertise

During these medical meetings, Clearside aims to present compelling evidence of their position as leaders in the field of suprachoroidal delivery. Victor Chong, MD, MBA, the company's Chief Medical Officer, articulated enthusiasm for the CLS-AX program, which is designed to offer a six-month therapeutic impact comparable to other intravitreal therapies. This innovative approach enables physicians to provide more personalized treatment schedules, minimizing the need for more frequent interventions.

Recent Presentations Focusing on Suprachoroidal Delivery

Recent sessions highlight the use of Clearside’s SCS Microinjector, which facilitates the detailed and targeted administration of therapies. Upcoming presentations include:

• Hawaiian Eye & Retina 2025 (January 18-24, 2025)
  Presentation topics include advancements in suprachoroidal delivery mechanisms with discussions from experts such as Dr. Judy E. Kim and Dr. Rishi P. Singh.
• 3rd Annual Ophthalmic Drug Delivery Summit (January 28-30, 2025)
  Presentations will explore the cutting-edge techniques for targeted drug delivery within the ocular compartment.

Looking Ahead: CLS-AX Focused Sessions

In addition to discussing current advancements, Clearside is poised to present key data from its Phase 2b ODYSSEY clinical trial focusing on the CLS-AX program. Future presentations include:

• Angiogenesis, Exudation, and Degeneration 2025 (Virtual; February 8, 2025)
  Presentation of results from the Phase 2b CLS-AX ODYSSEY trial.
• The Macula Society Annual Meeting (February 12-15, 2025)
  Discussing top-line results for suprachoroidal CLS-AX trials.

Innovative SCS Microinjector and Its Capabilities

Clearside’s SCS delivery method opens unprecedented pathways to target the back of the eye for sight-threatening conditions. The innovative SCS Microinjector is a sophisticated device that allows physicians to administer drugs precisely, minimizing side effects and enhancing therapeutic outcome.

The microinjector utilizes sterile, microneedle technology to deliver a wide array of compounds directly into the SCS, optimizing the localized effect while preserving surrounding healthy tissues. This precision is vital in ensuring patient safety and maximizing the efficacy of treatments.

Achievements from the ODYSSEY Clinical Trial

The ODYSSEY trial has showcased promising results, establishing its primary objectives related to visual acuity and the safety profile of CLS-AX. Participants receiving CLS-AX exhibited remarkable outcomes, experiencing a sustained therapeutic effect that could significantly alter the treatment landscape in wet AMD management.

This trial demonstrated that an impressive proportion of participants did not require further treatment for extended periods following the initial injection, reflecting the promising nature of Clearside's innovative drug delivery system.

Vision for Future Developments

As Clearside Biomedical continues to explore the extensive potential of its CLS-AX program and suprachoroidal delivery, the company aims to expand its therapeutic pipeline across various retinal diseases. The advancements made in this area are vital not only to the company but also to the potentially transformative effects on patient management and outcomes. Clearside also maintains an active interest in partnerships that strengthen its position within the ophthalmic innovation landscape.

Company Overview: Clearside Biomedical, Inc.

Clearside Biomedical is at the forefront of biopharmaceuticals focused on ocular therapies. With an unwavering commitment to delivering effective and targeted treatments, the company has developed the SCS Microinjector and several pipeline initiatives aiming to enhance the efficacy of existing therapies and introduce new solutions for previously untreatable conditions.

Frequently Asked Questions

What is Clearside Biomedical's primary focus?

Clearside Biomedical primarily concentrates on revolutionizing ocular therapy delivery using their proprietary suprachoroidal space injection technology.

What is the CLS-AX program?

The CLS-AX program is a clinical initiative aiming to assess the safety and efficacy of suprachoroidally administered axitinib for the treatment of wet AMD.

When will Clearside present its latest clinical findings?

Clearside Biomedical will showcase its latest findings at various upcoming medical conferences in early 2025.

How does the SCS Microinjector work?

The SCS Microinjector delivers medication directly into the suprachoroidal space, allowing for targeted treatment to reduce side effects and enhance efficacy.

What are the potential advantages of suprachoroidal delivery?

Suprachoroidal delivery may offer improved safety and individualized dosing schedules compared to traditional intravitreal therapies.

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