Exciting 3-Year Results on Hypoparathyroidism Treatment Unveiled
New Findings on Hypoparathyroidism Treatment
Recently, Ascendis Pharma A/S (NASDAQ: ASND) revealed significant data from its Phase 2 PaTH Forward Trial, focusing on adults battling hypoparathyroidism. This trial, which encompassed approximately 57 participants, highlighted the transformative effects of TransCon™ PTH (also known as palopegteriparatide) over a 3-year period. These findings were notably presented at the recent annual meeting of the American Society for Bone and Mineral Research.
Understanding Hypoparathyroidism
Hypoparathyroidism is a complex endocrine disorder characterized by insufficient levels of parathyroid hormone (PTH). This hormone plays a crucial role in managing calcium and phosphate levels in the body. Individuals suffering from hypoparathyroidism may face a plethora of complications that can be both severe and life-threatening. Some of these include neuromuscular irritability, renal issues, and cognitive impairment. Most cases arise post-surgery, but other causes can include autoimmune conditions.
The Role of TransCon PTH
TransCon PTH is designed as a prodrug of parathyroid hormone (PTH [1-34]). Administered daily, its unique formulation ensures that patients receive a consistent and prolonged exposure to the active hormone throughout the dosing period. This continuous delivery aims to mimic the natural hormone response, thereby facilitating improved bone remodeling and overall skeletal health.
Clinical Trial Highlights
During the trial, participants demonstrated notable improvements in various skeletal dynamics. The results indicated that long-term treatment with palopegteriparatide not only normalized bone remodeling but also improved bone quality, bringing it closer to what is typically seen in individuals with sufficient parathyroid function. Dr. Mishaela Rubin, a prominent expert in bone health, emphasized these results during her oral presentation at ASBMR 2024.
Contribution to Bone Health
The impact of TransCon PTH extends beyond merely assisting with hormone levels. The trial results suggest that sustained use of palopegteriparatide can significantly promote skeletal health, aligning parameters with those typically expected from healthier states of parathyroid function. This breakthrough presents a hopeful avenue for patients suffering from chronic hypoparathyroidism.
About Ascendis Pharma
Ascendis Pharma A/S is dedicated to the development of innovative therapies through its proprietary TransCon technology platform. The company is driven by its core values of prioritizing patients, advancing scientific research, and fostering a passionate approach towards healthcare. Their headquarters resides in Copenhagen, Denmark, with further operations established across Europe and the United States.
Frequently Asked Questions
What is hypoparathyroidism?
Hypoparathyroidism is an endocrine disorder marked by insufficient levels of parathyroid hormone, impacting calcium and phosphate balance.
What are the results of the Phase 2 PaTH Forward Trial?
The trial's results indicate that long-term treatment with TransCon PTH maintains bone health and normalizes bone remodeling in patients.
Who presented the findings at ASBMR 2024?
Dr. Mishaela Rubin, an esteemed medical professor, shared the results during her oral presentation at the conference.
What does TransCon PTH do?
TransCon PTH is designed to deliver a steady supply of parathyroid hormone to improve skeletal health and treat hypoparathyroidism.
Where is Ascendis Pharma located?
Ascendis Pharma is headquartered in Copenhagen, Denmark, with additional facilities in Europe and the U.S.
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