Eurostars Grant Fuels Innovative Gene Therapy for Dry AMD

Groundbreaking Collaboration for Dry AMD Gene Therapy

Phenocell, a renowned biotechnology company, has joined forces with Amarna Therapeutics, a trailblazer in gene therapies, to develop an innovative gene therapy for Dry Age-Related Macular Degeneration (Dry AMD). This partnership has been bolstered by the recent award of a Eurostars grant, aimed at advancing research in this critical area of ophthalmology.

Understanding the Challenge of Dry AMD

Dry AMD is a prevalent condition that leads to vision loss and impacts millions globally. With an estimated 200 million cases worldwide, this number is projected to rise significantly in the coming decades. Unfortunately, there is currently no effective cure, making the need for innovative treatments more crucial than ever. Both Phenocell and Amarna recognize the urgency of developing viable solutions in this field.

The Promise of Nimvec™ Gene Therapy

At the core of their collaborative efforts is Amarna's proprietary Nimvec™ gene delivery platform, which has shown exceptional potential in preclinical studies. This vehicle is designed to not only deliver therapeutic genes but also inhibit inflammation and promote tissue regeneration. By utilizing this technology, the research team aims to evaluate the effectiveness of Nimvec™ in combating Dry AMD.

Creating a 3-Dimensional Retinal Model

To assess the efficacy of the Nimvec™ platform, Phenocell will develop a sophisticated 3-dimensional in vitro cellular disease model. This model will incorporate iPSC-derived retinal pigment epithelium (RPE) cells, microglial cells, and photoreceptor cells, closely mimicking the complex environment of the human retina. This advanced model will facilitate the testing of therapeutic strategies and provide invaluable insights into disease mechanisms.

Expert Insights from Phenocell and Amarna Leadership

Dr. Brigitte Onteniente, R&D and Site Leader at Phenocell, expressed her enthusiasm for the collaboration, highlighting the unique capabilities offered by iPSC-derived cells in creating disease models. She stated, "The Eurostars grant emphasizes the importance of this project and the profound impact it could have in addressing unmet clinical needs in ophthalmology." Likewise, Dr. Henk Streefkerk, CEO of Amarna, noted that their partnership with Phenocell is pivotal for advancing gene therapy technologies, enhancing the therapeutic potential assessment of their candidates.

Impact of the Eurostars Grant

The Eurostars program, supported by the European Union, encourages innovative research and development projects led by small to medium enterprises (SMEs). The recognition of the AMD-HALT project under this program underscores its significance in advancing knowledge in retinal disease treatment and bridging gaps in current medical solutions.

Support from Catalyze

The successful acquisition of this grant is attributed to the specialized assistance provided by Catalyze, an organization proficient in grant writing and project development. Their guidance has been essential in transforming the AMD-HALT project from vision to reality.

Future Perspectives on Dry AMD Treatment

The introduction of a gene therapy specifically aimed at Dry AMD marks a significant step in addressing a disease that has remained largely untreated. With the projected growth of the AMD market, valued at €10 billion, there is increasing motivation for companies like Phenocell and Amarna to invest in innovative research. The collaboration opens new avenues for treatment modalities that can fundamentally change patient outcomes.

About Phenocell and Amarna Therapeutics

Phenocell is a prominent player in the biotechnology ecosystem, offering advanced stem cell-derived models that aid in drug discovery. Based in France, the company is dedicated to providing researchers with relevant tools for studying complex diseases.

Amarna Therapeutics, on the other hand, is focused on developing cutting-edge gene therapies that target both genetic disorders and prevalent inflammatory diseases. The Nimvec™ vector platform is a testament to Amarna's commitment to innovation in therapeutic delivery.

Frequently Asked Questions

What is the Eurostars grant awarded to Phenocell and Amarna?

The Eurostars grant is a funding initiative from the European Union that supports innovative R&D projects led by small to medium enterprises, such as the AMD-HALT project focusing on Dry AMD treatments.

What is Dry AMD?

Dry AMD is a chronic eye condition that leads to progressive vision loss, with no current effective treatment. It poses significant health concerns, affecting millions worldwide.

How does Nimvec™ gene therapy work?

Nimvec™ is a proprietary gene delivery vector developed by Amarna that aims to deliver therapeutic genes while also inhibiting inflammation and promoting regeneration in affected tissues.

What role does the 3-dimensional retinal model play in the research?

The 3-dimensional retinal model developed by Phenocell will replicate the human retinal environment, allowing for more accurate assessment of the gene therapy's efficacy and mechanism.

How will this research impact future treatment options for Dry AMD?

This collaboration seeks to pave the way for effective treatments for Dry AMD, potentially transforming patient care and management of the disease moving forward.

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