Entera Bio Unveils Groundbreaking Oral GLP-2 Therapy Data
Entera Bio's Promising Developments in Oral GLP-2 Therapy
Entera Bio Ltd., a leading innovator in oral peptide therapies, is breaking new ground with their first-in-class oral GLP-2 tablet. This advancement is particularly crucial for individuals suffering from Short Bowel Syndrome (SBS), offering hope where daily injections have been the norm.
A Game-Changer for Short Bowel Syndrome Patients
Short Bowel Syndrome is a challenging condition that arises when a significant portion of the intestine is missing or does not function properly. This results in severe malabsorption of nutrients and can lead to malnutrition and other serious health issues. Currently, approximately 30,000 patients struggle with SBS, relying on daily injections of Gattex® (teduglutide), the only approved GLP-2 therapy that requires inconvenient and often painful administration.
Key Findings Presented by Entera Bio
At a recent medical congress, Entera Bio shared positive pharmacokinetic data regarding their oral GLP-2 therapy aimed at enhancing patient care. The data indicated remarkable improvements in efficacy and potential user compliance, reflecting significant advancements over existing therapies.
Promising Pharmacokinetic Outcomes
- Extended Half-Life: The oral GLP-2 tablet exhibited a plasma half-life of roughly 15 hours in preclinical studies with minipigs. This is a substantial improvement compared to the 0.85 hours observed with teduglutide, highlighting the tablet's prolonged effects.
- Robust Oral Bioavailability: The therapy’s peak plasma concentrations reached around 200 ng/ml, a number significantly exceeding the 36.8 ng/ml observed with teduglutide in humans, demonstrating the tablet's potential effectiveness and efficiency.
- Sustained Exposure: With systemic exposure maintained for over 24 hours and low variability, this development supports a once-daily dosing schedule, simplifying treatment for patients.
- Favorable Safety Profile: Encouragingly, no toxicity was observed during preclinical studies, which bodes well for its future use in patients.
Transforming Treatment Paradigms
Miranda Toledano, CEO of Entera Bio, expressed her enthusiasm regarding the findings, stating that this oral GLP-2 therapy could revolutionize the treatment landscape for SBS. This innovative approach offers a less invasive, more manageable treatment option, allowing for personalized dosing tailored to individual patient needs, which is significant given the complex nature of SBS.
About Entera Bio Ltd.
Entera Bio is at the forefront of developing oral peptide therapies for conditions where traditional treatments pose significant challenges. They utilize the N-Tab™ platform to create innovative oral formulations that hold the potential to change lives. Their extensive pipeline includes therapies targeting various conditions beyond IBS, focusing on those with pressing medical needs.
Looking Ahead: Future of Therapy for SBS
The advancements presented by Entera Bio represent a hopeful shift in treating SBS, moving away from daily injections towards a more convenient oral treatment. As this research progresses, it opens doors not only for SBS but also for broader applications of their groundbreaking oral peptide technology, potentially influencing healthcare strategies across the medical landscape.
Frequently Asked Questions
What is Entera Bio Ltd.'s new oral GLP-2 therapy?
Entera Bio's new therapy is a first-in-class oral GLP-2 tablet designed for patients with Short Bowel Syndrome, offering a more convenient alternative to daily injections.
How does the new oral therapy compare to current treatments?
The oral GLP-2 therapy demonstrated a significantly longer half-life and higher plasma concentrations compared to existing treatments, indicating potential for improved efficacy.
What are the potential benefits of this therapy for SBS patients?
This therapy could transform treatment by providing an easy-to-administer oral option, enhancing compliance and personalizing treatment dosages for better health outcomes.
What stage is Entera Bio's oral GLP-2 therapy currently in?
The therapy has recently presented promising preclinical data, and further clinical development will follow based on this positive feedback.
How can I learn more about Entera Bio?
For more information, you can visit Entera Bio's official website or follow their updates on various social media platforms for the latest news.
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