Duality Biologics and BeiGene Forge Key Collaboration

Duality Biologics Secures Major Milestone with BeiGene

Duality Biologics, a pioneering biotech firm, is excited to share that BeiGene, Ltd. has officially exercised its exclusive option for the B7H4 antibody-drug conjugate (ADC) DB1312/BG-C9074. This significant move grants BeiGene global rights for the development, manufacturing, and commercialization of this innovative investigational product. As part of this agreement, DualityBio received an option exercise fee along with a milestone payment related to the advancement of Phase I dose-escalation studies.

Details of the Agreement

In the latter half of 2023, specifically July, the company revealed that BeiGene had entered into an agreement to obtain an exclusive option for a comprehensive clinical and commercial license for the preclinical ADC therapy, tailored for patients with select solid tumors. The terms of this agreement included an upfront payment to DualityBio, alongside additional payments predicated on BeiGene's exercise of its option. The total potential earnings could reach up to $1.3 billion, supplemented by tiered royalties based on future sales.

About Duality Biologics

Founded with the vision to redefine cancer and autoimmune disease treatment, Duality Biologics is deeply committed to developing next-generation ADCs. The company has made significant strides in establishing state-of-the-art ADC technology platforms that hold global intellectual property rights. By focusing on building a robust product pipeline, DualityBio is actively conducting clinical trials in 17 countries, with over 1,500 patients participating in various clinical-stage ADC programs.

Innovative ADC Technology

Alongside its dedicated research efforts, DualityBio has formed strategic alliances with numerous multinational corporations and leading biotech innovators. This collaborative approach has positioned DualityBio as a global leader in the ADC space, where the company is pioneering efforts to create “Super ADCs.” This includes innovative developments in bispecific ADCs, novel payload ADCs, and ADCs aimed at treating autoimmune disorders.

Commitment to Patients

At the heart of Duality’s mission is a commitment to enhance the lives of patients facing cancer and autoimmune diseases. The company's relentless pursuit of innovative therapies reflects its dedication to meeting the urgent medical needs of these patient populations. With a pipeline rich in potential, DualityBio is poised to make significant contributions to the field of oncology.

Frequently Asked Questions

What is the significance of the agreement between Duality Biologics and BeiGene?

This agreement marks a pivotal achievement for DualityBiologics, allowing BeiGene to develop and commercialize the promising B7H4 ADC, potentially leading to significant advancements in cancer treatment.

What are ADCs and how do they work?

Antibody-drug conjugates (ADCs) are targeted cancer therapies that link a powerful drug to an antibody specifically designed to bind to cancer cells, ensuring that the treatment is directed precisely where it is needed, thereby minimizing side effects.

What future developments can we expect from Duality Biologics?

Duality Biologics is actively expanding its pipeline with several clinical trials and innovative ADCs, including bispecific and novel payload ADCs, aimed at addressing unmet medical needs in oncology and autoimmune disorders.

How is Duality Biologics impacting the cancer treatment landscape?

By focusing on the development of next-generation ADCs and strategic collaborations, Duality Bio aims to enhance treatment outcomes and provide more effective options for patients battling cancer.

Where can I find more information about Duality Biologics?

For additional information on their programs and innovations, you can visit their official website at www.dualitybiologics.com.

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