Doer Biologics Advances DR10624 with Phase 2 Patient Dosing
Doer Biologics Shares Breakthrough News in Clinical Trials
Zhejiang Doer Biologics Co., Ltd. ("Doer Bio"), an innovative player in the realm of metabolic disease and cancer treatments, recently celebrated a significant milestone. The company announced the successful dosing of the first patient in its Phase 2 clinical trial for DR10624, a tri-specific agonist aimed at addressing severe hypertriglyceridemia (SHTG). This announcement marks a major step forward in developing effective therapies for individuals struggling with this condition.
Understanding the Phase 2 Study Objectives
The ongoing Phase 2 trial is designed as a randomized, placebo-controlled, double-blind study. It aims to evaluate the efficacy and safety of three different dosages of DR10624 in adult patients diagnosed with severe hypertriglyceridemia. To qualify for the study, participants must have fasting triglyceride levels exceeding 5.65 mmol/L (500 mg/dL) during preliminary screenings. With an enrollable count of 72 participants, the outcomes of this trial could potentially lead to significant advancements in treatment protocols.
Details of DR10624's Mechanism of Action
DR10624 stands out as a first-in-class therapeutic agent, skillfully targeting key metabolic receptors: the Fibroblast growth factor 21 receptor (FGF21R), the Glucagon-like peptide-1 receptor (GLP-1R), and the glucagon receptor (GCGR). Engineered via Doer Bio's proprietary MultipleBody® platform, this tri-agonist is crafted to deliver balanced metabolic activity. Preclinical studies showcased DR10624's remarkable potency in promoting weight reduction, lowering triglyceride levels, normalizing lipid profiles, and enhancing overall liver functionality.
Implications of Severe Hypertriglyceridemia
Severe hypertriglyceridemia is a pressing health concern. Patients suffering from this condition are at an increased risk of experiencing acute pancreatitis and atherosclerotic cardiovascular disease (ASCVD). The importance of this Phase 2 study cannot be overstated, as it aspires to identify the optimal dose that will be pivotal for future Phase 3 clinical trials. The data generated through this study could illuminate new paths for managing SHTG, ultimately leading to better patient outcomes.
Statements from Doer Biologics Leadership
Dr. Yanshan Huang, the founder and CEO of Doer Bio, expressed enthusiasm regarding the trial's commencement. He remarked, "DR10624 is designed to bring hope to patients with severe hypertriglyceridemia. Our commitment to advancing this treatment reflects our dedication to addressing significant unmet medical needs."
Complementing this sentiment, Dr. Yongliang Fang, COO of Doer Bio, added, "We are thrilled to progress toward potential solutions for patients dealing with severe hypertriglyceridemia, a condition often overlooked in terms of treatment options."
About Zhejiang Doer Biologics Co., Ltd.
Founded with a vision to transform the healthcare landscape, Zhejiang Doer Biologics Co., Ltd. is committed to developing multi-specific biotherapeutics using advanced platform technologies. These innovations include xLONGylation®, MultiBody®, AccuBody®, and SMART-VHHBody. Doer Bio’s focus remains on targeting unmet medical needs, especially in metabolic disorders and oncology.
As the company continues to innovate, its efforts underscore the importance of scientific advancement in addressing pressing health issues.
Frequently Asked Questions
What is DR10624?
DR10624 is a tri-specific agonist developed by Doer Biologics aimed at treating severe hypertriglyceridemia.
What is the goal of the Phase 2 study?
The Phase 2 study aims to evaluate the safety and efficacy of DR10624 in patients with severe hypertriglyceridemia.
How many participants are involved in the trial?
A total of 72 participants will be enrolled in this Phase 2 clinical trial.
What are the risks associated with severe hypertriglyceridemia?
Patients with this condition are at a higher risk of developing severe complications, including acute pancreatitis and cardiovascular diseases.
How does DR10624 function?
DR10624 works by targeting key receptors important in metabolic regulation, potentially improving various metabolic parameters.
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