DiaMedica Therapeutics Develops Expert Board for DM199's Preeclampsia Trials

DiaMedica's Commitment to Preeclampsia Treatment

DiaMedica Therapeutics Inc. (Nasdaq: DMAC) has taken a significant step in the realm of maternal-fetal health by announcing its newly formed Scientific Advisory Board (SAB). This board will play an integral role in the development of DM199, a proprietary recombinant serine protease specifically targeted for the treatment of preeclampsia (PE). As a clinical-stage biopharmaceutical company, DiaMedica is dedicated to creating innovative therapies for severe ischemic diseases, and the establishment of this board marks an exciting chapter in their journey.

Expertise Behind the Scientific Advisory Board

Welcoming Renowned Specialists

The SAB is comprised of a distinguished group of professionals recognized for their contributions to the field of preeclampsia and maternal-fetal health. Rick Pauls, DiaMedica’s President and CEO, expressed enthusiasm about the caliber of expertise joining the company. He stated, "We are thrilled to welcome these distinguished doctors to our Scientific Advisory Board. Their expertise and guidance will be invaluable as we work to advance treatment options for this potentially fatal condition." This sentiment showcases DiaMedica's commitment to leveraging expert insights for groundbreaking advancements.

Members of the Scientific Advisory Board

The well-respected individuals joining the SAB include:

Professor Vincenzo Berghella is a leading figure in maternal-fetal medicine at Thomas Jefferson University. With an extensive background, he brings invaluable experience, having contributed to around 700 peer-reviewed publications.

Professor Cathy Cluver, an expert from Stellenbosch University, is known for her extensive research in preeclampsia, successfully leading trials that address novel therapeutic approaches.

Professor Bob Silver from the University of Utah is renowned for his work on complications of pregnancy, including preeclampsia, further enriching the board with his clinical insights.

Professor Stephen Tong has been identified as a top expert in preeclampsia, with groundbreaking translational research that has led multiple concepts to clinical trials globally.

Professor Susan Walker, an esteemed figure at the University of Melbourne, focuses on improving detection and outcomes for preeclampsia, highlighted by her numerous contributions to the academic literature.

The Significance of Preeclampsia

Preeclampsia is a serious condition that can arise during pregnancy, characterized by high blood pressure and organ damage. Affecting up to 8% of pregnancies globally, it poses severe risks to both the mother and child, including stroke and premature delivery. Current treatment options remain limited, as no approved therapeutics exist for this condition in major regions such as the United States or Europe.

Research Developments and Clinical Trials

The Phase 2 Trial of DM199

In line with its commitment to advancing therapeutic options for preeclampsia, DiaMedica is conducting a Phase 2 clinical trial of DM199. This study, which will involve up to 90 women with preeclampsia, aims to assess the safety and efficacy of DM199 in lowering maternal blood pressure and improving uterine artery dilation. These findings are crucial in understanding whether DM199 can be a significant addition to treatment protocols for affected women.

Understanding DM199

DM199, also known as rinvecalinase alfa, is a recombinant form of human tissue kallikrein-1. It is being studied not only for treating preeclampsia but also for acute ischemic stroke, showcasing its versatility. The primary purpose of DM199 in the context of preeclampsia is to enhance maternal endothelial health and improve the blood flow to both maternal organs and the placenta, addressing critical pathways that can lead to a healthier outcome for both mother and baby.

About DiaMedica Therapeutics Inc.

DiaMedica Therapeutics Inc. focuses on developing innovative treatments for severe ischemic diseases, particularly acute ischemic stroke and preeclampsia. Their lead therapeutic agent, DM199, represents a promising approach in medical science, and the company is dedicated to improving the health and well-being of those affected by serious conditions. For more information, please visit the company’s website.

Frequently Asked Questions

What is the purpose of the Scientific Advisory Board formed by DiaMedica?

The SAB aims to provide expertise and guidance in the development of DM199 for the treatment of preeclampsia, enhancing research and clinical strategies.

Who are the members of the Scientific Advisory Board?

The SAB includes Professors Vincenzo Berghella, Cathy Cluver, Bob Silver, Stephen Tong, and Susan Walker, all experts in maternal-fetal health.

What condition does DM199 aim to treat?

DM199 is being developed to treat preeclampsia, a pregnancy-related disorder that can have serious implications for mothers and their babies.

How does DM199 work in treating preeclampsia?

DM199 is designed to enhance endothelial health, reduce maternal blood pressure, and improve blood perfusion to maternal organs and the placenta.

What are the potential risks associated with preeclampsia?

Preeclampsia can lead to severe complications such as stroke, organ damage, and premature delivery, posing risks to both the mother and child.

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