Cytokinetics to Present Novel Research at Major Heart Conferences

Cytokinetics Highlights Key Presentations for 2025

In a significant announcement from Cytokinetics, Incorporated (NASDAQ: CYTK), the company revealed its participation in upcoming presentations addressing critical advancements in the treatment of hypertrophic cardiomyopathy (HCM). The events aim to emphasize the contributions of Cytokinetics in clinical research and the development of innovative therapies. The scientific sessions will take place on November 7-10, 2025, showcasing findings that have significant implications for patient care.

Important Upcoming Scientific Sessions

The presentations are scheduled to feature cutting-edge research linked to the MAPLE-HCM study, presenting the latest findings regarding the safety and efficacy of Aficamten in treating patients with obstructive HCM. These sessions will occur at two prominent venues, including the Hypertrophic Cardiomyopathy Medical Society and the American Heart Association.

Hypertrophic Cardiomyopathy Medical Society Scientific Sessions

This prestigious gathering will present groundbreaking research, including three notable Late Breaking Science presentations. One significant focus will be the Effect of Aficamten vs Metoprolol on Patient-Reported Health Status in Obstructive Hypertrophic Cardiomyopathy. This presentation by Dr. Michael E. Nassif is scheduled for November 7, 2025. The session will inspire dialogues on patient outcomes that stem from these advanced therapies.

Highlights of Presentations

Key topics will encompass:

• Long-term Impact of Aficamten on Patient-Reported Outcome Measures: Led by Dr. Shepard D. Weiner, this presentation aims to unveil findings from the FOREST-HCM study, scheduled for the same day as Dr. Nassif's session.
• Assessing Outcomes Following Septal Myectomy: Presented by Dr. Daniel Kamna, this poster presentation provides valuable insights into surgical outcomes for young patients facing obstructive HCM.

Insights from the American Heart Association Scientific Sessions 2025

Further expanding upon their commitment, Cytokinetics will also participate in the American Heart Association Scientific Sessions, which runs concurrently with the Hypertrophic Cardiomyopathy meetings. Here, the company plans to present findings from the MAPLE-HCM study and other trials that resonate with pressing cardiovascular issues.

Late Breaking Science Presentations

Highlighted topics include:

• Clinical Responses to Aficamten Monotherapy: This analysis conducted by Dr. Andrew Wang compares the effectiveness of Aficamten against Metoprolol in addressing disease burden in obstructive HCM.
• Impact of Aficamten on Biomarkers: Research shared by Dr. Neal K. Lakdawala from Harvard Medical School will delve into the biological indicators that support the efficacy of ongoing treatments.

Progress and Innovation at Cytokinetics

Cytokinetics has carved its niche as a pioneering biopharmaceutical company specializing in cardiac muscle dysfunction. With more than 25 years of innovative research under its belt, it is preparing for potential regulatory approvals for Aficamten following encouraging results from its pivotal Phase 3 studies. This investigational cardiac myosin inhibitor demonstrates promising outcomes for patients suffering from obstructive HCM.

Research and Development Focus

The company is rigorously advancing research on additional therapies aimed at heart failure and cardiac health, including:

• Omecamtiv mecarbil, intended for patients with heart failure and reduced ejection fraction.
• Ulacamten, targeting heart failure with preserved ejection fraction.
• CK-089, a specialized treatment for individuals with specific muscular disorders.

Frequently Asked Questions

What are the main highlights of Cytokinetics' upcoming presentations?

The presentations will focus on innovative research related to Aficamten and its benefits for patients with obstructive hypertrophic cardiomyopathy.

Who will present at the Hypertrophic Cardiomyopathy Medical Society session?

Dr. Michael E. Nassif, along with other experts, will present findings related to patient-reported outcomes and the effects of Aficamten.

When are the American Heart Association Scientific Sessions scheduled?

The sessions are planned for November 7-10, 2025, featuring discussions on significant heart failure trials.

What is Aficamten?

Aficamten is an investigational cardiac myosin inhibitor being evaluated for its effectiveness in treating heart conditions like obstructive HCM.

How can I learn more about Cytokinetics?

For more details on their advancements and products, visit the Cytokinetics website.

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