Crinetics Pharmaceuticals Advances Neuroendocrine Tumor Research

Revolutionizing Neuroendocrine Tumor Treatment

Crinetics Pharmaceuticals, Inc. (NASDAQ: CRNX) is excited to showcase significant advancements in neuroendocrine tumor (NET) research at the upcoming North American Neuroendocrine Tumor Society Annual Meeting. This event, known as NANETS 2025, will be held from October 23-25, bringing together experts and enthusiasts in the field to discuss the latest findings and innovations.

Presentation of Clinical Data

During this prestigious meeting, Crinetics will present three impactful abstracts from its clinical development programs. Dana Pizzuti, M.D., Chief Medical and Development Officer at Crinetics, expressed enthusiasm about the opportunity to share progression-free survival data for paltusotine, which is used in treating carcinoid syndrome associated with NETs. This marks a significant step forward as it highlights the effectiveness of this treatment option.

Key Findings from Clinical Trials

The Phase 2 trial data on paltusotine will be made publicly available through a poster presentation, showcasing a remarkable 74% investigator-assessed progression-free survival rate after one year of treatment for patients suffering from carcinoid syndrome caused by NETs. This data reflects the potential of paltusotine to greatly enhance the quality of life for patients dealing with this challenging condition.

Expanding Indications for Paltusotine

Paltusotine, which is marketed in the U.S. as PALSONIFY™, is already an approved treatment for adults with acromegaly who have not had successful outcomes from surgery. This drug is now being explored for additional uses, particularly in the treatment of carcinoid syndrome, where it currently awaits regulatory approval in various markets.

Insights into Additional Clinical Programs

Beyond the promising results from the Phase 2 study, Crinetics will also shed light on two other clinical trials relating to NETs. The first involves pivotal Phase 3 data from a randomized, placebo-controlled study of paltusotine, while the second pertains to an NDC candidate CRN09682. This novel drug targets somatostatin receptor 2-expressing tumors, offering hope in the treatment landscape.

Details of the Presentations

Below are key details of the abstracts Crinetics will present at NANETS 2025:

• Title: Investigator-Assessed Disease Progression in a Phase 2 Study of Paltusotine in Patients with Neuroendocrine Tumors and Carcinoid Syndrome
• Date/Time: October 23, 2025; 5:15 pm – 6:30 pm
• Title: CAREFNDR: Phase 3, Randomized, Placebo-Controlled Study of Paltusotine in Adults With Carcinoid Syndrome Due to Well-Differentiated Neuroendocrine Tumors
• Date/Time: October 23, 2025; 5:15 pm – 6:30 pm
• Title: First-in-Human Study of a Novel Nonpeptide Drug Conjugate (CRN09682) in Patients With Somatostatin Receptor 2-Expressing Tumors
• Date/Time: October 23, 2025; 5:15 pm – 6:30 pm

About Paltusotine

Paltusotine is a revolutionary nonpeptide drug that selectively targets somatostatin receptor type 2 (SST2), and is now in Phase 3 clinical trials for carcinoid syndrome linked to NETs. Early results have shown positive effects in reducing flushing episodes and bowel movements, which are common symptoms for those afflicted with carcinoid syndrome. Its FDA approval for acromegaly demonstrates its effective therapeutic profile.

Exploring CRN09682

The investigational drug CRN09682 represents a potentially first-in-class approach for NETs. By linking a somatostatin receptor agonist to a cytotoxic agent, this innovative drug aims to enhance the delivery of anti-tumor effects to the targeted tumor cells while minimizing side effects, thus presenting a valuable concept in cancer therapy.

About Crinetics Pharmaceuticals

Crinetics is dedicated to improving treatment options for endocrine diseases and associated tumors. With a strong focus on developing and commercializing therapies that engage G-protein coupled receptors, Crinetics is pioneering patient-centered solutions in the pharmaceutical landscape. Their leading treatment, PALSONIFY™, highlights this commitment, as does their robust pipeline, which includes numerous programs targeting varying endocrine conditions.

Frequently Asked Questions

What is the purpose of the NANETS Annual Meeting?

The NANETS Annual Meeting serves as a platform for sharing the latest research and developments in neuroendocrine tumors, bringing together professionals to discuss advancements in treatment options.

What is paltusotine used for?

Paltusotine is primarily used to treat acromegaly and is currently being investigated for its effectiveness in treating carcinoid syndrome.

How effective is paltusotine for carcinoid syndrome?

The data shows a 74% progression-free survival rate among patients with carcinoid syndrome after one year of treatment.

What is CRN09682?

CRN09682 is an investigational nonpeptide drug conjugate designed to target and treat neuroendocrine tumors that express somatostatin receptor 2.

How does Crinetics Pharmaceuticals contribute to endocrine health?

Crinetics focuses on developing innovative therapies that address endocrine diseases, aiming to improve patient outcomes and expand treatment options.

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