Cognition Therapeutics Unveils Promising Outcomes of Zervimesine

Highlights from Cognition’s SHIMMER Study

– The SHIMMER study showcased significant therapeutic benefits in patients dealing with dementia with Lewy bodies (DLB) –

– Participants receiving zervimesine showed impressive outcomes in behavioral, cognitive, and motor functions compared to those on placebo –

PURCHASE, N.Y. – Cognition Therapeutics, Inc. (NASDAQ: CGTX), a clinical-stage company focused on innovative solutions for neurodegenerative disorders, has announced the upcoming oral presentation of the topline results from their Phase 2 SHIMMER study at the International Lewy Body Dementia Conference (ILBDC). Dr. James E. Galvin, the director of the Comprehensive Center for Brain Health at the University of Miami Miller School of Medicine, will present these groundbreaking findings.

Impressive Results of Zervimesine Therapy

Dr. Galvin expressed enthusiasm about sharing the results, emphasizing the critical importance of communicating the efficacy observed among participants treated with zervimesine (CT1812) to an international audience. "DLB presents unique challenges due to its intricate symptoms that can progress rapidly. Our study highlighted that zervimesine-treated individuals outperformed their placebo counterparts across several metrics," he noted.

The Phase 2 SHIMMER study engaged 130 adults diagnosed with mild-to-moderate DLB, randomly assigning them to receive either zervimesine or a placebo for six months. The primary endpoints focused on the safety and tolerability of the treatment. Promising data indicated that patients on zervimesine demonstrated an impressive 86% improvement in behavioral outcomes, specifically on the neuropsychiatric inventory (NPI A-L). This tool assesses various behavioral symptoms, including hallucinations and anxiety, which are common in DLB patients.

Significant Improvements in Patient Quality of Life

The reductions in debilitating symptoms not only benefited the patients but also eased the distress experienced by their caregivers. Zervimesine participants performed 52% better in daily living activities, such as self-care tasks, compared to those on placebo. Remarkably, a notable 91% reduction in cognitive fluctuations was observed in the zervimesine group, a common and distressing symptom of DLB.

Moreover, zervimesine therapy led to a 62% improvement in motor functions, showcasing its capability to enhance overall physical performance. Dr. Galvin highlighted the crucial role such improvements play in allowing older adults with DLB to maintain their independence and bond with their families.

Safety Profile and Continuing Research

The SHIMMER study also established zervimesine's favorable safety profile, with most treatment-related side effects being mild to moderate, aligning with earlier clinical findings. This positive safety data is pivotal as Cognition Therapeutics proceeds with their dedication to further clinical investigations.

The study’s infrastructure and funding were robust, supported by a notable grant from the National Institute on Aging, totaling around $30 million, allowing comprehensive investigation into the benefits of zervimesine.

What is Zervimesine?

Zervimesine (CT1812) is an experimental drug formulated to navigate the blood-brain barrier and engage selectively with the sigma-2 receptor complex. This mechanism targets the underlying issues caused by harmful protein interactions and oxidative stress that lead to significant cognitive impairment.

About Cognition Therapeutics, Inc.

Cognition Therapeutics, Inc. is pioneering the development of small molecule therapeutics that aim to treat neurodegenerative diseases effectively. Currently, they are advancing zervimesine's clinical trials focusing on DLB and Alzheimer's, demonstrating their commitment to improving patient outcomes and enhancing quality of life.

Frequently Asked Questions

What are the key findings of the SHIMMER study?

The SHIMMER study demonstrated that zervimesine significantly outperformed placebo in terms of behavioral, cognitive, and functional metrics in patients with DLB.

What specific improvements were observed in patients treated with zervimesine?

Patients on zervimesine showed an 86% improvement in behavioral outcomes, reduced cognitive fluctuations by 91%, and had better motor function than those on placebo.

Who presented the SHIMMER study results?

Dr. James E. Galvin, the study director, presented the findings at the ILBDC.

What was the safety profile of zervimesine?

The SHIMMER study indicated that zervimesine had a favorable safety and tolerability profile, with most adverse events being mild to moderate.

How is Cognition Therapeutics enhancing its research efforts?

Cognition Therapeutics is expanding its studies on zervimesine, supported by substantial funding, and aims to advance further treatments for neurodegenerative diseases.

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