Cognition Therapeutics Champions Awareness for Lewy Body Dementia
Raising Awareness for Lewy Body Dementia
Cognition Therapeutics, Inc. (NASDAQ: CGTX), a leading clinical-stage biopharmaceutical company, is staunchly supporting Lewy Body Dementia Awareness Month. This initiative emphasizes the urgent need for enhanced research and treatment options for individuals affected by dementia with Lewy bodies (DLB). Approximately 1.4 million people in the U.S. live with this challenging condition, which is the second most common form of progressive dementia, and currently, there are no approved therapies available.
Understanding Lewy Body Dementia
DLB is a complex neurodegenerative disorder characterized by the accumulation of alpha-synuclein proteins in the brain, forming Lewy bodies. These deposits disrupt normal neuron function, leading to a gradual deterioration in both cognitive abilities and motor skills. The symptoms of DLB can vary significantly among patients and may change in intensity over time, making diagnosis and management particularly difficult. Key symptoms include cognitive impairment, visual hallucinations, REM sleep behavior disorder, and motor issues similar to those seen in Parkinson’s disease.
The Importance of Raising Awareness
Lisa Ricciardi, CEO of Cognition Therapeutics, shared, "Lewy Body Dementia Awareness Month presents an important opportunity to bring to light this often underdiagnosed condition that can significantly impact patients and their families. At Cognition, we are dedicated to creating new treatment pathways for neurodegenerative disorders like DLB. Our leading candidate, CT1812, might hold promise for addressing the intricate pathological mechanisms involved in this disease."
Collaborative Efforts and Upcoming Trial Results
Cognition Therapeutics is collaborating with renowned experts from the Lewy Body Dementia Association (LBDA) and the University of Miami Miller School of Medicine to execute the Phase 2 SHIMMER trial. This significant trial has enrolled 130 patients diagnosed with mild-to-moderate DLB at various centers of excellence throughout the United States. The topline results from this trial are highly anticipated and are expected to shed light on the therapeutic impact of CT1812 on the diverse symptoms experienced by DLB patients.
Community Voices at the EL-PFDD Meeting
Moreover, the DLB community will be participating in the inaugural Externally Led Patient-Focused Drug Development (EL-PFDD) Meeting, which will offer patients and caregivers the platform to share their experiences directly with the FDA. Anthony Caggiano, M.D., Ph.D., Cognition's Chief Medical Officer, stated, "We are eager to hear first-hand from patients about the most pressing challenges they face due to DLB. This feedback will be invaluable as we refine our development strategy for CT1812."
About CT1812 and the SHIMMER Study
CT1812 is an experimental orally administered small molecule that has been designed to cross the blood-brain barrier and selectively bind to the sigma-2 receptor complex. The preclinical and clinical data suggest that CT1812 can displace toxic protein aggregates, thereby potentially alleviating some of the cellular dysfunctions that contribute to diseases like DLB and Alzheimer’s disease.
The SHIMMER study serves as a crucial Phase 2 clinical trial aimed at identifying signals of efficacy in 130 adults with mild-to-moderate DLB. Participants are randomized to receive either a placebo or one of two once-daily doses of CT1812 (100 mg or 300 mg) for a duration of six months. This study is notably supported by approximately $30 million in grant funding from the National Institute on Aging, and it involves collaboration with experts in the field.
About Cognition Therapeutics
Cognition Therapeutics, Inc. focuses on discovering and developing groundbreaking therapeutics intended for age-related degenerative disorders affecting the central nervous system and retina. Their lead candidate, CT1812, is under investigation for clinical programs targeting Alzheimer's disease, Lewy body dementia, and dry age-related macular degeneration (dry AMD). The company is committed to advancing its pipeline of sigma-2 receptor modulators to create effective treatment options that stand apart from traditional methods.
Frequently Asked Questions
What is Lewy Body Dementia?
Lewy Body Dementia (DLB) is a progressive form of dementia characterized by the deposition of alpha-synuclein proteins in the brain, leading to cognitive and motor decline.
How many people are affected by DLB?
Approximately 1.4 million people in the United States are impacted by Lewy Body Dementia, making it the second most common type of dementia.
What is CT1812?
CT1812 is an experimental small molecule being developed by Cognition Therapeutics, designed to target the sigma-2 receptor complex and potentially mitigate the effects of toxic protein aggregates in neurodegenerative disorders.
What is the SHIMMER Study?
The SHIMMER Study is a Phase 2 clinical trial that aims to assess the effectiveness of CT1812 in patients with mild-to-moderate Lewy Body Dementia and has enrolled 130 participants.
How can I get involved in DLB awareness activities?
Individuals can participate in awareness activities by joining local support groups, attending seminars, and engaging with organizations like the Lewy Body Dementia Association to stay informed and contribute to the cause.
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