Codexis Unveils Innovations in siRNA Manufacturing at TIDES

Codexis Unveils Innovations in siRNA Manufacturing at TIDES

Recently, Codexis, Inc. (NASDAQ: CDXS) showcased significant advancements at the TIDES USA conference, held in San Diego. The company revealed its proprietary ECO Synthesis platform, which aims to enhance the manufacturing efficiency of small interfering RNA (siRNA) therapies. Presentations noted how these advances are set to revolutionize the production process by reducing purification costs and improving overall performance in siRNA manufacturing.

Leadership Insights on siRNA Technology

Stephen Dilly, the Chief Executive Officer of Codexis, expressed his excitement about the growing momentum in the industry. He stated, "siRNA technology has officially arrived," marking a significant shift towards enzymatic manufacturing solutions. The latest initiatives focused on reshoring manufacturing capabilities align perfectly with Codexis' ECO Synthesis technology deployment, confirming its efficacy and scalability in real-world applications.

Highlighting Process Improvements

Codexis' presentations during the event highlighted their impressive achievements using inclisiran as a case study. By leveraging immobilized enzymes within the ECO Synthesis platform, the company achieved remarkable results, including:

• Consistent coupling efficiency exceeding 98%
• High product quality throughout the manufacturing process
• A reduction in average cycle time by around 24%
• High yields with 30 grams of siRNA produced per liter

This innovative approach promises to minimize or eliminate costly downstream purification steps, thereby attracting significant interest from pharmaceutical companies looking to optimize their manufacturing methods.

Machine Learning Enhancements in Ligation Processes

A key point of discussion was Codexis' newly launched machine learning tool that enhances the ligation success rate for producing siRNA. This tool optimizes the pairing of ligases and RNA fragments, reportedly improving efficiency four- to sixfold compared to traditional methods. The streamlined design process enables the integration of multiple fragments in a single reaction with over 90% efficiency, ultimately shortening the time needed for process development.

Collaborative Success with CDMOs

Three key Contract Development and Manufacturing Organizations (CDMOs)—Bachem, Nitto Avecia, and ST Pharm—also presented their findings on using Codexis ligases to combine short RNA fragments effectively in their facilities. Each organization demonstrated how they successfully replicated Codexis' ligation processes, confirming the system's versatility and productivity in different production environments.

Control Over Stereochemistry During Synthesis

Another milestone presented by Codexis involved advancements in controlling stereochemistry during siRNA synthesis. This capability aims to address the challenges presented by chemical synthesis methods that often yield unwanted mixtures of oligonucleotide mirror images. The ECO Synthesis platform allows for tailored control over stereochemistry, providing a distinct advantage to developers concerning the therapeutic potency and stability of their siRNA therapeutics.

Upcoming Conference Call and Investor Information

Codexis management is scheduled to host a conference call to delve into the details of the data presented at TIDES and explore implications for future developments. Investors and interested parties can join the call and access the accompanying webcast for in-depth insights. Confirmations and additional materials, including slide decks from the conference, are accessible in the Investor Relations section of the Codexis website.

About Codexis

Codexis stands as a leading provider of enzymatic solutions tailored for efficient therapeutics manufacturing. By leveraging its proprietary CodeEvolver technology, the company develops high-performance enzymes crucial for addressing real-world challenges within small molecule pharmaceuticals and nucleic acid synthesis. The ongoing development of the ECO Synthesis manufacturing platform signifies a major step towards enabling scalable RNAi therapeutic production through enzyme-driven processes, poised to make significant improvements in yield, energy efficiency, and waste reduction in manufacturing.

Frequently Asked Questions

What is the ECO Synthesis platform?

The ECO Synthesis platform is Codexis’ proprietary technology designed to improve the manufacturing efficiency of siRNA therapeutics through enzymatic methods.

How does Codexis’ machine learning tool function?

This tool optimizes the pairing of ligases and RNA fragments, significantly enhancing the efficiency of the ligation process for producing siRNA.

Who are Codexis’ main collaborators in siRNA manufacturing?

Codexis collaborates with several CDMOs, including Bachem, Nitto Avecia, and ST Pharm, which have all successfully implemented Codexis technologies in their operations.

What advancements were discussed regarding stereochemistry?

Codexis highlighted progress in gaining control over stereochemistry during oligonucleotide synthesis, enabling drug developers to improve the efficacy of their therapeutic products.

Where can I find more information about Codexis?

More information regarding Codexis, including their technological advancements and investor updates, is available on their official website.

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