Climb Bio Showcases CLYM116 in IgA Nephropathy Webcast Event

Climb Bio to Host Engaging Webcast on CLYM116

Climb Bio, Inc. (NASDAQ: CLYM), a leading biotechnology company in the development of therapeutics for immune-mediated diseases, is gearing up for an informative webcast focusing on their innovative CLYM116 program. This significant event will take place at 8:00 a.m. ET on September 29, 2025. Leading the session will be Climb Bio's management team, together with Dr. Craig E. Gordon, a prominent nephrologist with two decades of experience in treating patients with IgA nephropathy (IgAN).

Understanding IgA Nephropathy and CLYM116

The webcast will provide valuable insights into IgAN, shedding light on the unmet medical needs and the commercial opportunities that lie ahead. This condition, characterized by the deposition of IgA antibodies in the kidneys, leads to inflammation and potential renal failure. It presents a critical target for new therapeutic approaches, making the development of CLYM116 particularly timely.

CLYM116: A Unique Therapeutic Approach

CLYM116 is a preclinical monoclonal antibody that targets APRIL (A Proliferation-Inducing Ligand), which is influential in the activity of pathogenic B cells in autoimmune diseases. It employs a cutting-edge 'sweeper' mechanism that enhances its efficacy by recycling itself while eliminating APRIL. This innovative approach has the potential to establish CLYM116 as a leader in its category, providing effective treatment with less frequent dosing.

Event Highlights and Webcast Access

During the event, participants can expect:

• An overview of IgAN and the pressing needs within this field;
• Insights from preclinical data that include comparative results from studies with nonhuman primates against earlier anti-APRIL monoclonal antibodies;
• A breakdown of Climb Bio’s strategic development plans for CLYM116 moving forward.

To access the live webcast, interested parties should visit the “Investors and News” section on the Climb Bio website. A replay will be available approximately two hours after the event and can be accessed for a minimum of 30 days thereafter.

About Climb Bio and Its Pipeline

Climb Bio, Inc. is driven by the mission to develop novel therapeutics that can significantly improve the lives of patients suffering from immune-mediated conditions. Beyond CLYM116, the company is also advancing budoprutug, an anti-CD19 monoclonal antibody with promising potential to treat a broad spectrum of B-cell mediated diseases. The ongoing research into CLYM116 reflects the company's commitment to addressing critical needs in healthcare.

Broader Implications of CLYM116

With its unique design, CLYM116 shows promise not just for IgAN but also has implications for treating other diseases linked to B-cell activity, demonstrating the versatility and potential impact of this therapeutic candidate in creating lasting changes in management practices across various conditions.

Frequently Asked Questions

What is the focus of Climb Bio's upcoming webcast?

The webcast will highlight the CLYM116 program and its applications in treating IgA nephropathy, featuring expert discussions and preclinical data.

Who is presenting during the webcast?

Climb Bio’s management team will present, along with nephrologist Dr. Craig E. Gordon, who specializes in IgA nephropathy.

How can I access the CLYM116 webcast?

The live webcast can be accessed through the “Investors and News” section on the Climb Bio website. A replay will also be available for later viewing.

What is the mechanism of action of CLYM116?

CLYM116 targets APRIL, enhancing therapeutic efficacy by employing a unique recycling mechanism that promotes its therapeutic potential and safety profile.

When is CLYM116 expected to progress to clinical trials?

Climb Bio plans to advance CLYM116 into Phase 1 clinical trials following regulatory approvals and completion of its IND-enabling studies.

About The Author

Olivia Taylor here, a 26-year-old writer and financial advisor. After earning a degree in finance, I worked in the sector for years. I've always loved numbers and had a talent for simplifying difficult financial ideas so that anyone could understand. I wrote my first book because of this passion; it helps readers take charge of their financial futures by fusing real-life stories with useful financial advice.

Whether they are just beginning their careers, preparing for significant life events, or seeking to invest wisely, my goal with my writing is to enable people to make educated financial decisions. The foundation of my work is the conviction that security and freedom of the individual are largely determined by financial literacy. To further financial education, I run workshops and frequently write for financial blogs in addition to my books.

I like to travel, experience other cultures, and find inspiration in daily life when I'm not writing or examining market trends. My passion is utilizing sound financial practices to help people reach their financial objectives and lead the best lives possible.

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