Circle Pharma Unveils Promising Preclinical Findings for CID-078
Circle Pharma Showcases Innovative CID-078 Findings
Circle Pharma, a clinical-stage biopharmaceutical company based in South San Francisco, is dedicated to developing cell-permeable macrocycle therapies that have the potential to transform cancer treatment. Recently, the company has announced a significant milestone by sharing preclinical data on its first-and-only-in-class cyclin A/B RxL inhibitor, CID-078, at the World Conference on Lung Cancer.
Breakthrough Results with CID-078
CID-078 has shown remarkable capabilities in inducing single-agent tumor regressions in preclinical models of small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). Initial studies indicate that tumor models with elevated E2F targets and marked G2M checkpoint scores reveal a significant inhibition of tumor growth upon treatment with CID-078. This effect was observed with doses that are clinically achievable, establishing a strong foundation for further exploration.
Understanding the Mechanism of Action
The activity of CID-078 is notably correlated with the expression levels of E2F1 and ESPL1, aligning with its proposed mechanism of cyclin A/B RxL inhibition, which leads to DNA damage. This novel approach represents an innovative avenue for targeting oncogenic pathways that drive cancer progression.
Future Clinical Trials and Studies
The promising results from preclinical studies suggest that CID-078 could serve as a viable monotherapy option for patients battling these challenging forms of cancer. Circle Pharma is poised to advance CID-078 into a phase 1 clinical trial, marking a crucial step in the journey to bringing this therapy to patients in need.
About the CID-078 Program
CID-078 is designed as an orally bioavailable macrocycle that adeptly targets tumor cells exhibiting oncogenic alterations leading to cell cycle dysregulation. This dual-action inhibitor effectively disrupts the protein interactions crucial for cell cycle progression, showcasing its potential in preclinical xenograft models where significant tumor regressions have been documented.
Circle Pharma's Commitment to Innovation
Circle Pharma is at the forefront of developing unique macrocycle therapies, utilizing its proprietary MXMO™ platform, which integrates advanced synthetic chemistry with structure-based drug design. The company is committed to addressing significant unmet clinical needs, specifically focusing on cyclins, which are pivotal in regulating cell cycle progression and are often implicated in various cancers.
Connecting with Circle Pharma
The company is dedicated to an accessible approach in delivering treatments that can effectively penetrate cells across multiple routes, including oral delivery methods. This advancement not only reflects Circle Pharma's commitment to innovation but also its goal of enhancing patient care through more adaptable and effective medications.
Frequently Asked Questions
What is CID-078?
CID-078 is a first-and-only-in-class cyclin A/B RxL inhibitor designed to treat small-cell and non-small-cell lung cancer.
How does CID-078 work?
The inhibitor works by disrupting protein interactions crucial for cell cycle progression, leading to tumor growth inhibition and regression.
What stage is Circle Pharma in with CID-078?
Circle Pharma is preparing to enter phase 1 clinical trials for CID-078, following promising preclinical results.
What types of cancer does CID-078 target?
CID-078 targets small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC), both of which present significant treatment challenges.
How can I learn more about Circle Pharma?
You can explore more about Circle Pharma's innovative therapies and research initiatives by visiting their official website.
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