Cellectar Biosciences to Share Pediatric Cancer Research Insights
New Developments at Cellectar Biosciences
Recently, Cellectar Biosciences, Inc., a clinical biopharmaceutical company, announced the acceptance of a significant abstract for presentation at the American Association for Cancer Research (AACR) Special Conference focused on Pediatric Cancer. This notable event, where experts gather to discuss the latest in cancer research, will unfold over several days. Cellectar is poised to share promising interim data regarding their innovative treatment, iopofosine I 131, specifically targeting pediatric high-grade gliomas, a vital area of study as these tumors can be particularly aggressive.
Details of the Presentation
The oral presentation at the conference will take place within a plenary session designed for critical discussions about pediatric oncology treatments. Jarrod Longcor, the Chief Operating Officer of Cellectar, will present the findings from their CLOVER-2 trial, which includes children with relapsed or refractory pediatric high-grade glioma (r/r pHGG). This presentation is part of an ongoing effort to address the urgent need for effective therapies in a patient population that faces very limited options.
Key Presentation Information
The specific details of the presentation are outlined as follows:
- Title: "Precision Radiotherapy for Incurable Brain Tumors: Phase 1b Dose & Regimen Optimization Study of Iopofosine I 131 in Inoperable Relapsed or Refractory Pediatric High-Grade Glioma, Interim Data Assessment"
- Session: Plenary Session 3: From Targets to Trials: Rethinking How We Design Child-First Medicine
- Track: Scientific Presentations: Navigating the landscape of pediatric oncology modalities
- Date/Time: September 26, 2025, 2:50 PM Eastern time
- Presenter: Jarrod Longcor
Understanding Pediatric High-Grade Gliomas
Pediatric high-grade gliomas are aggressive brain tumors that significantly impact the young population. The patients involved in the CLOVER-2 trial have varied diagnoses ranging from diffuse midline gliomas (DMG) to anaplastic ependymomas. The standard median progression-free survival (PFS) for those with relapsed pHGG remains grim at only a few months. Thus, exploring innovative treatment avenues such as iopofosine I 131 is crucial for improving patient outcomes.
Insights from the CLOVER-2 Trial
The ongoing CLOVER-2 trial is dedicated to evaluating the safety and effectiveness of iopofosine I 131 in treating r/r pHGG among young patients. This study is being conducted across multiple sites in the United States and Canada, carefully examining the drug’s tolerability and potential to enhance overall survival rates. Various dosing protocols are being explored, and this research could open new doors for treating this challenging condition.
About Cellectar Biosciences
Cellectar Biosciences is dedicated to the development of targeted cancer treatments, leveraging its proprietary Phospholipid Drug Conjugate™ (PDC) platform. Their goal is to improve therapeutic efficacy while minimizing adverse effects. With an evolving pipeline of innovative drugs, which includes iopofosine I 131 tailored for targeted delivery of iodine-131, Cellectar is in a prominent position to make a difference in the oncology field.
Additional assets in their pipeline, like CLR 121225 and CLR 121125, are focused on other solid tumors, demonstrating the breadth of Cellectar's commitment to fighting cancer.
Looking Ahead
The data to be shared at the upcoming AACR conference is part of Cellectar’s forward-thinking approach towards addressing the unmet needs within pediatric oncology. As the company continues its efforts in drug development for complex cancers, it remains eligible for pivotal designations from the FDA, enhancing its capabilities to lead in innovative cancer solutions.
Frequently Asked Questions
What is the focus of the presentation by Cellectar Biosciences?
The presentation will highlight interim data from the Phase 1b trial of iopofosine I 131 for treating pediatric high-grade gliomas.
When and where will the presentation take place?
The presentation is scheduled for September 26, 2025, during the AACR Special Conference on Pediatric Cancer.
Who will present the findings?
Jarrod Longcor, the Chief Operating Officer of Cellectar, will be the presenter.
What are pediatric high-grade gliomas?
These are aggressive brain tumors that can significantly affect children's health and require innovative treatment options.
What is iopofosine I 131?
It is a targeted therapy designed for delivering iodine-131 to tumor cells, aimed at enhancing treatment effectiveness while reducing side effects.
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