Laureate Announced for Hamm International Prize for Diabetes Research
Honoree has made outstanding contributions toward understanding the pathogenesis and prevention of Type 1 diabetes
The prestigious Harold Hamm International Prize for Biomedical Research in Diabetes, awarded by OU Health Harold Hamm Diabetes Center at the University of Oklahoma Health Sciences, recognizes remarkable contributions to the field. This esteemed award will be given to Professor Dr. Anette-Gabriele Ziegler, who leads the Institute of Diabetes Research at Helmholtz Munich, German Research Center for Environmental Health. Dr. Ziegler is celebrated for her groundbreaking research into understanding the pathogenesis of Type 1 diabetes and her endeavors in early diagnostics and preventive strategies.
Why the Hamm Prize Matters
The Hamm Prize holds significant importance as it not only celebrates individual achievements but also inspires further research in Type 1 and Type 2 diabetes. It is awarded to those demonstrating lifelong dedication to the field or making exceptional advances that promise to bring a cure closer. This prestigious honor includes a generous award of $250,000, recognized globally as the largest of its kind.
Dr. Ziegler expressed her gratitude, stating, "The award is an incredible motivation to look ahead and continue on the path toward understanding the pathogenesis of Type 1 diabetes and developing preventive therapies – with the ultimate goal of finding a cure." She reflects the innovative spirit that the Hamm Prize embodies, aiming to change lives and enhance health outcomes across populations.
A Brief History of the Hamm Prize
The Hamm Prize was established in 2012 and is named after Harold Hamm, the chairman and CEO of Continental Resources Inc., who generously provided an endowment for its funding. The award is conferred every two years by an esteemed jury made up of leading figures in the diabetes research community.
In remarks regarding Dr. Ziegler’s achievements, Hamm stated, "This prize honors work that changes the course of science – and Dr. Ziegler's research does exactly that. Her leadership in uncovering how Type 1 diabetes begins and how we might stop it before it starts is the kind of bold, life-changing progress this prize was meant to recognize. Her work fuels our hope – and brings us all one step closer to the cure."
Dr. Ziegler's Pioneering Research Contributions
Dr. Ziegler has made significant strides in diabetes research, translating essential questions into practical studies and implementing findings into public health initiatives. Some of her remarkable contributions include:
- Launching BabyDiab, a pioneering birth cohort that investigates the onset of Type 1 diabetes.
- Initiating Fr1da, a public screening program designed to detect early signs of Type 1 diabetes, now a model for global initiatives.
- Leading GPPAD (Global Platform for the Prevention of Autoimmune Diabetes), which translates disease pathogenesis knowledge into clinical trials for Type 1 diabetes prevention, enrolling over 2,000 infants for genetic risk assessment.
- Conducting research that paved the way for FDA approval of teplizumab, the first immunotherapy shown to delay the onset of Type 1 diabetes in at-risk individuals.
Transformative Discoveries in Diabetes Research
Dr. Ziegler's discoveries have reshaped our understanding of diabetes, revealing critical insights such as:
- Autoimmunity to insulin is a crucial initial factor that leads to Type 1 diabetes in children.
- Islet autoimmunity can begin in early childhood, with heightened incidence around ages one to two.
- Children with multiple islet autoantibodies are highly likely to develop diabetes.
- Early life respiratory infections, including those caused by COVID-19, can significantly increase the risk of islet autoimmunity among genetically susceptible children.
- Initial changes in glucose levels and immune responses often precede the onset of insulin autoimmunity.
Dr. Ziegler emphasizes the interplay between her patient care and research, asserting that her clinical experiences provide invaluable insights into her scientific inquiries. She declares, "A researcher is the best doctor," showcasing her dedication to applying research findings directly to patient care.
The Hamm Prize ceremony will take place during an elaborate gala in October, celebrating Dr. Ziegler's accomplishments. Jed Friedman, Ph.D., director of the Harold Hamm Diabetes Center, highlights that her research efforts significantly enhance our understanding of Type 1 diabetes prevention.
Friedman remarked, "Professor Dr. Ziegler's visionary leadership and unwavering commitment have advanced scientific understanding and laid the groundwork for innovative interventions to improve patient outcomes by delaying Type 1 diabetes onset. Her work exemplifies the integration of rigorous research with compassionate clinical practices, embodying the ideals of medical science. We are privileged to honor her contributions to diabetes research and her lasting impact on public health."
Frequently Asked Questions
Who is the recipient of the Hamm International Prize this year?
The recipient is Professor Dr. Anette-Gabriele Ziegler, recognized for her significant contributions to diabetes research.
What is the purpose of the Hamm Prize?
The Hamm Prize aims to recognize and promote advancements in diabetes research and encourages significant contributions toward a cure.
How much is the Hamm Prize worth?
The Hamm Prize includes a monetary award of $250,000, the largest of its kind globally.
When was the Hamm Prize established?
The Hamm Prize was established in 2012 to honor significant advancements in diabetes research.
Why is Dr. Ziegler's research important?
Dr. Ziegler's research enhances the understanding of Type 1 diabetes, paving the way for early diagnosis and preventative strategies.
