Castle Biosciences Advances Uveal Melanoma Management with PRAME

Castle Biosciences Reinforces Its Leadership in Uveal Melanoma Care

Castle Biosciences, Inc. (Nasdaq: CSTL), known for enhancing patient care through innovative diagnostic tests, has made significant strides in managing uveal melanoma, a rare yet aggressive form of eye cancer. This progress was underscored by the findings from the Collaborative Ocular Oncology Group Study No. 2 (COOG2.1), conducted by Harbour et al., which recently highlighted the essential role of the PRAME biomarker in conjunction with the DecisionDx-UM test.

Real-World Validation of DecisionDx-UM Test

During the recent Association for Research in Vision and Ophthalmology (ARVO) meeting, Castle Biosciences presented new data from a substantial cohort of 1,297 patients. This research reinforced the effectiveness of the DecisionDx-UM test, which evaluates gene expression profiles to predict the risk of metastatic disease in patients diagnosed with uveal melanoma.

Combining DecisionDx-UM and PRAME for Enhanced Insights

Dr. Rebecca Critchley-Thorne, vice-president of research and development at Castle Biosciences, expressed enthusiasm for the study's implications, stating that the integration of PRAME gene expression data with DecisionDx-UM results can lead to better risk stratification. This combination provides physicians with a more nuanced understanding of metastatic risks, enabling them to devise optimal surveillance and treatment strategies tailored to each patient's unique situation.

Presentation Details at ARVO

At the ARVO 2025 Annual Meeting, Castle presented a series of findings that further elucidated the relationship between PRAME status and the genomic profile of tumors in uveal melanoma. Specifically, linking PRAME results with the DecisionDx-UM test can discern finer distinctions within Class 1 and Class 2 tumors, stratifying them based on whether they are PRAME positive or negative. This classification holds the potential to inform treatment decisions better, enhancing overall patient management.

A Collaborative Effort for Better Outcomes

The research employed a collaboration with the National Cancer Institute’s Surveillance, Epidemiology, and End Results (NCI SEER) Program, significantly enriching the data pool for this study. These efforts aim to build on the original findings of the COOG2.1 study, validating that the combined reporting of DecisionDx-UM class and PRAME status offers crucial insights regarding the likelihood of metastasis, leading to better treatment pathways.

The Importance of DecisionDx-UM

The DecisionDx-UM test has become a cornerstone in the management of newly diagnosed uveal melanoma across numerous ocular oncology practices in the United States. This test, which utilizes patient-specific tumor biology, has received recognition within clinical guidelines as a vital prognostic factor for assessing metastatic risk and guiding differential surveillance regimens.

Continuous Innovation in Cancer Diagnostics

Castle Biosciences is committed to advancing the field of oncology diagnostics. The company’s comprehensive repertoire of tests not only targets uveal melanoma but expands into various cancers, addressing significant clinical needs in areas like skin cancers and Barrett’s esophagus. Their ongoing research continues to explore new ways to refine patient management and improve outcomes through the development of innovative tests, such as one aimed at guiding therapy for patients with atopic dermatitis.

Contact for More Information

For media inquiries, reach out to Allison Marshall at marshall@castlebiosciences.com. Investors can connect with Camilla Zuckero via czuckero@castlebiosciences.com to learn more about the company's efforts and strategic direction.

Frequently Asked Questions

What is the DecisionDx-UM test?

The DecisionDx-UM test is a 15-gene expression profile test that predicts the risk of metastasis in patients with uveal melanoma by analyzing individual tumor biology.

How does the PRAME biomarker contribute to cancer treatment?

The PRAME biomarker, when used with the DecisionDx-UM test, provides additional insights that help refine the risk stratification for patients with uveal melanoma, potentially improving treatment strategies.

What are the main findings presented at the ARVO meeting?

The main findings highlight the long-term performance of the DecisionDx-UM test, emphasizing how adding PRAME results further clarifies metastatic risks in uveal melanoma patients.

Why is uveal melanoma considered an aggressive cancer?

Uveal melanoma is classified as aggressive due to its potential to metastasize rapidly, necessitating precise diagnostic tools to manage treatment effectively.

How can I learn more about Castle Biosciences and its tests?

Visit the Castle Biosciences website for comprehensive information on their oncology tests and ongoing research initiatives to advance patient care.

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