Carisma and Moderna Team Up for New Autoimmune Therapies
Carisma and Moderna Team Up for New Autoimmune Therapies
Carisma Therapeutics Inc. (NASDAQ: CARM), a clinical-stage biopharmaceutical company, has announced an exciting expansion of their collaboration with Moderna, Inc. (NASDAQ: MRNA) to develop groundbreaking in vivo CAR-M therapies for autoimmune diseases. This partnership aims to leverage both companies' leading-edge technologies in the field of immunotherapy, marking a significant step forward from their previous work in oncology.
Expansion of the Collaboration
The collaboration builds on Carisma’s successful pre-clinical in vivo CAR-M data seen in cancer treatments. Under the newly expanded agreement, Carisma has identified two specific autoimmune disease targets that will be the focus of their joint efforts. This significant move allows Carisma to retain all rights for additional autoimmune disease targets beyond the two nominated, which will be uniquely aligned with Moderna.
Innovative Technological Integration
By fusing Carisma's proprietary CAR-M technology with Moderna's advanced mRNA/LNP platform, both companies are set to pioneer new macrophage engineering strategies aimed at these autoimmune targets. Carisma will oversee the discovery and optimization of development candidates, while Moderna will take charge of clinical development and eventual commercialization of the resulting therapies.
Leadership Statements Highlighting a Vision
Steven Kelly, President and CEO of Carisma, expressed his enthusiasm about this collaboration, remarking, "Expanding our work with Moderna into the realm of autoimmune diseases is a notable milestone for our mission to harness macrophages in treating a variety of illnesses. Our CAR-M technology holds transformative potential for patients facing these challenging conditions." This sentiment is echoed by Lin Guey, PhD, CSO of Therapeutic Research Ventures at Moderna, who stated, "Building upon our advancements in CAR-M therapies with Carisma allows us to venture beyond oncology, and we believe our combined expertise can lead to meaningful innovations for patients."
Potential Impact on Disease Treatment
The collaboration envisions bringing forward innovative therapies that could positively impact a wide array of disease areas, particularly cancer and autoimmune diseases. By advancing the field of immunotherapy, this partnership is anticipated to set new standards in how we approach treatment for diverse and debilitating health conditions.
About Carisma Therapeutics
Carisma Therapeutics is dedicated to the development of advanced immunotherapies utilizing a novel macrophage and monocyte engineering platform. Their goal is to address cancer and serious diseases with transformative solutions. By focusing on engineered macrophages and monocytes, which play critical roles in immune responses, Carisma is poised to lead in this innovative therapeutic landscape. More details about their work can be found on their official website.
Frequently Asked Questions
What is the purpose of the Carisma and Moderna collaboration?
The collaboration aims to develop in vivo CAR-M therapies specifically targeting autoimmune diseases.
What technology is being used in this collaboration?
The partnership combines Carisma's proprietary CAR-M technology with Moderna's mRNA and lipid nanoparticle platform.
What are the roles of Carisma and Moderna in this agreement?
Carisma is responsible for discovering and optimizing drug candidates, while Moderna leads clinical development and commercialization.
How many autoimmune disease targets are being pursued?
The expansion includes the nomination of two specific autoimmune disease targets for detailed development.
What is the expected impact of this collaboration?
The partnership is designed to advance immunotherapy treatment options for patients suffering from cancer and autoimmune diseases.
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