Can-Fite Advances Pancreatic Cancer Treatment with New Study
Can-Fite's Groundbreaking Clinical Study for Pancreatic Cancer
Study aims to improve safety and efficacy for patients
Can-Fite BioPharma Ltd. has made significant strides in the fight against pancreatic cancer by securing authorization from the Israeli Ministry of Health to conduct a Phase IIa clinical trial. This study will evaluate the effect of Namodenoson, an innovative oral treatment, with the goal of establishing both safety and clinical efficacy in patients suffering from this severe form of cancer.
The Importance of the Phase IIa Clinical Trial
Namodenoson, which has been identified as a promising option for pancreatic cancer, will undergo a multicenter, open-label trial. The trial will target patients who have advanced pancreatic adenocarcinoma, specifically those whose conditions have progressed after at least one line of therapy. This determination is crucial as it opens the door for patients who may have limited treatment options.
Dr. Fishman, Can-Fite's Chief Scientific Officer and Executive Chairman, expressed optimism regarding the potential of Namodenoson, citing encouraging preliminary results from preclinical research. The study will administer Namodenoson at a dose of 25 mg twice daily for 28 consecutive days, ensuring careful monitoring of patient safety throughout the trial.
What the Study Will Address
This study's primary objective is to assess the safety profile of Namodenoson while secondary objectives will gauge clinical activity through various metrics, including the Objective Response Rate (ORR) and Progression-Free Survival (PFS). The results derived from the study could not only enhance our understanding of pancreatic cancer treatment but also potentially offer new hope for patients combating this aggressive disease.
A Closer Look at Namodenoson
Namodenoson is a small-molecule drug known for its high selectivity towards the A3 adenosine receptor (A3AR). This receptor is predominantly expressed in diseased cells, which gives Namodenoson its favorable safety profile and enhances its potential as a treatment option. Previously, Namodenoson has been evaluated in Phase II trials for hepatocellular carcinoma and conditions like NASH (non-alcoholic steatohepatitis).
Can-Fite's Vision for the Future
Can-Fite BioPharma not only aims to advance treatment for pancreatic cancer but is also dedicated to addressing a portfolio of oncological and inflammatory diseases. The company received Orphan Drug Designation for Namodenoson in the U.S. and Europe, further underscoring its commitment to innovating within the realm of cancer treatment.
Company Overview and Growth Potential
Positioned as a clinical-stage drug development company, Can-Fite BioPharma continues to broaden its therapeutic reach with extensive drug pipelines. The developments of its lead candidate Piclidenoson, which has recently reported promising Phase III trial results, along with advancements in treatments for liver diseases, position the company for robust market growth. With more than 1,600 patients involved in clinical studies to date, Can-Fite demonstrates a strong commitment to safety and effectiveness across its drug offerings.
Additionally, the company has expanded its research into various cancers such as colon and prostate cancer, showing the versatility and potential of their investigational drugs.
Frequently Asked Questions
What was the recent approval received by Can-Fite?
Can-Fite received approval from the Israeli Ministry of Health for a Phase IIa clinical trial to evaluate Namodenoson in pancreatic carcinoma treatment.
What is Namodenoson?
Namodenoson is an orally bioavailable small-molecule drug that selectively targets the A3 adenosine receptor, showing promise in treating pancreatic cancer and other conditions.
How will the trial evaluate Namodenoson?
The trial will assess safety, clinical activity, and pharmacokinetics of Namodenoson in patients with advanced pancreatic adenocarcinoma.
What evidence supports Namodenoson's efficacy?
Preclinical studies have demonstrated its impressive anti-cancer effects and clear mechanism of action, encouraging enthusiasm among the research team.
What are Can-Fite's future plans?
Can-Fite plans to further evaluate Namodenoson for pancreatic cancer while also advancing treatments for other cancers and liver diseases to enhance patient outcomes.
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