Bruker Introduces Revolutionary 1.2 GHz NMR Spectrometer

Bruker Unveils Advanced 1.2 GHz NMR Spectrometer

Bruker is excited to announce its latest innovation, a 1.2 GHz Ascend™ Nuclear Magnetic Resonance (NMR) spectrometer, which has been accepted at the Swiss High-field NMR Facility operated by leading institutions. This cutting-edge instrument will significantly enhance research capabilities for various user groups, specifically in the domains of structural biology and advanced macromolecular analysis.

Transforming Research at Swiss High-field NMR Facility

The facility comprises locations at Biozentrum Basel and the University of Zürich. With the addition of this 1.2 GHz NMR, the facility aims to complement the existing 800 MHz NMR in Basel, enabling groundbreaking studies in protein structure determination and protein-protein interactions. The new spectrometer is specifically designed to facilitate detailed explorations into ligand binding and conformational fingerprinting.

Highlighting the Instrument's Capabilities

Professor Oliver Zerbe from the University of Zürich emphasized the potential of the 1.2 GHz NMR in studying G protein-coupled receptors (GPCRs) with unprecedented detail. This new instrument enhances resolution, allowing for extensive studies on how drug candidates interact with these crucial receptors. This comes as exciting news for the field, especially with Professor Ricarda Törner joining the team in 2025, who is set to utilize this resolution advantage in her research on intrinsically disordered proteins.

Impact on RNA Research

In addition, Professor Sigel's group anticipates significant advantages in their RNA research due to the high-resolution capabilities afforded by the new spectrometer, opening up new avenues for understanding RNA complexities.

Enhanced Detection Methods for Disease-Relevant Applications

Professor Stephan Grzesiek, who was instrumental in initiating this high-field NMR solution in Switzerland, expressed enthusiasm for the availability of such a high-field NMR. He mentioned that it would promote new NMR methods and advance detection limits in areas critical to understanding diseases, including GPCR signaling and cancer.

Exploring Chaperone-Client Complexes

Another area of research that will benefit greatly is the study of chaperone-client complexes at atomic resolution. According to Professor Sebastian Hiller, this fine level of detail will illuminate biophysical principles that govern chaperone function. Such insights are crucial for understanding neurodegenerative diseases, including Parkinson’s.

Commitment to Breakthrough Innovations

Professor Detlef Günther, who served as the Vice President of Research at ETH Zürich during the instrument's order placement, expressed his excitement about providing scientists with access to this ultra-high field NMR. He believes that this collaboration will lead to groundbreaking advancements in the field of structural biology and enhance our understanding of complex biological systems.

About Bruker Corporation

Bruker Corporation, a leader in the post-genomic era, empowers scientists and engineers to achieve remarkable discoveries and innovative applications that enhance the quality of human life. With high-performance scientific instruments and value-driven analytical and diagnostic solutions, Bruker facilitates exploration at molecular, cellular, and microscopic scales. Through close collaborations with customers, Bruker not only fosters innovation but also promotes improved productivity and success across various fields, including molecular and cell biology, applied and biopharma applications, and next-gen semiconductor metrology in support of AI technologies.

Bruker’s offerings encompass distinctive life science and diagnostic systems, aiding in preclinical imaging, proteomics, and multiomics research. By providing such comprehensive systems and solutions, Bruker further stands at the forefront of scientific exploration and discovery.

Frequently Asked Questions

What is the significance of the new 1.2 GHz NMR spectrometer?

The new 1.2 GHz NMR spectrometer significantly enhances research capabilities in structural biology, allowing for detailed studies in protein interactions and drug binding.

Which institutions operate the Swiss High-field NMR Facility?

The facility is collaboratively operated by the University of Basel, ETH Zürich, and the University of Zürich.

How does the 1.2 GHz NMR improve studies on GPCRs?

The higher resolution and enhanced dispersion available at this frequency allow researchers to better understand the dynamic behavior and drug interactions of GPCRs.

What biological issues does the new NMR address?

Among many applications, the new NMR will aid research into neurodegenerative diseases, including Parkinson’s, through better insights into protein dynamics.

How can Bruker’s technology impact human life?

Bruker’s advanced analytical and diagnostic solutions facilitate important scientific discoveries that can lead to improved healthcare, safety, and quality of life.

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