BridgeBio Highlights Groundbreaking Results on Heart Health

BridgeBio Unveils Key Outcomes from ATTRibute-CM Study

Palo Alto, California – BridgeBio Pharma, Inc. (NASDAQ: BBIO) is setting the stage for significant advancements in the treatment of transthyretin amyloid cardiomyopathy (ATTR-CM). The company has announced plans to present an array of findings from their ATTRibute-CM study at an upcoming major congress focused on heart failure.

At the Annual Congress of the Heart Failure Association of the ESC, several abstracts and moderated ePosters will be highlighted. These works showcase the clinical outcomes, quality of life improvements, and noteworthy analysis concerning atrial fibrillation events in patients undergoing treatment with acoramidis, a novel medication developed by BridgeBio.

Understanding the Importance of the ATTRibute-CM Study

The ATTRibute-CM study serves as an integral component of BridgeBio's strategy to address the significant impact of ATTR-CM, which affects countless individuals. This condition occurs when abnormal protein deposits accumulate in the heart, leading to serious complications. Treatments like acoramidis aim to stabilize these proteins and mitigate disease progression.

The upcoming presentations are expected to shed light on the effects of acoramidis on both serum TTR levels and patient-reported outcomes such as quality of life and functional capacity. These aspects are crucial as they determine the overall well-being of patients suffering from this challenging disease.

Details on the Presentations

During the congress, various presentations will cover a spectrum of findings:

Rapid-fire Abstract Summary

In a rapid-fire abstract, Dr. Anique Ducharme from Université de Montréal will discuss how acoramidis positively impacts serum TTR levels in patients with either wild-type or variant forms of ATTR-CM. This session is scheduled for May 20 at 8:30 am CEST.

Moderated ePoster Presentations

Additionally, Dr. Marianna Fontana from University College London will present two moderated ePosters on May 18, detailing: the effect of acoramidis on functional capacity and quality of life, as well as its influence on all-cause mortality, cardiovascular hospitalization, and NT-proBNP levels.

Moreover, Dr. Kevin Alexander from Stanford University will present findings on a post-hoc analysis indicating that treatment with acoramidis is associated with a lower incidence of atrial fibrillation-related events, demonstrating its potential to provide further protection for patients.

Exploring Disease Progression in Real-World Settings

Further insights into disease progression and mortality rates among patients with ATTR-CM will also be covered. Dr. Daniel P. Judge will share findings on the progression of ATTR-CM in real-world scenarios, highlighting critical information regarding the timing of diagnosis and treatment.

Moreover, Dr. Joshua Mitchell will discuss timelines from the first clinical manifestations to diagnoses of ATTR-CM, emphasizing the challenges in early detection.

The Role of Attruby™ in Managing ATTR-CM

Attruby, the brand name for acoramidis, is a transthyretin stabilizer designed to treat the cardiomyopathy of both wild-type and variant forms of transthyretin-mediated amyloidosis. It aims to reduce cardiovascular-related hospitalizations and improve overall patient outcomes, fundamental goals in managing this condition.

While clinical studies are promising, it is important for healthcare professionals to be aware of potentially adverse reactions associated with Attruby, which include diarrhea and abdominal pain. These considerations enhance the importance of monitoring patients closely during treatment.

About BridgeBio Pharma

BridgeBio Pharma is innovating the biopharmaceutical landscape, emphasizing the development of transformative medicines for genetic diseases. Established in 2015, the company is geared towards swiftly bringing advancements in genetic medicine to healthcare environments. With a passionate team of experts, BridgeBio remains dedicated to its mission of life-changing treatment.

Frequently Asked Questions

What is the main focus of BridgeBio's presentations at the upcoming congress?

BridgeBio is set to present significant findings on the clinical outcomes and quality of life improvements associated with acoramidis in the treatment of ATTR-CM.

Who are the key presenters representing BridgeBio at the congress?

Notable presenters include Dr. Anique Ducharme, Dr. Marianna Fontana, and Dr. Kevin Alexander, each providing insights on various aspects of the ATTRibute-CM study.

What are the key benefits expected from acoramidis for patients?

Acoramidis aims to improve serum TTR levels, enhance functional capacity, and reduce hospitalizations and adverse cardiovascular events in patients with ATTR-CM.

How does BridgeBio contribute to the field of genetic diseases?

BridgeBio focuses on discovering and developing innovative treatments for genetic diseases, aiming to transform patient outcomes and address unmet medical needs.

Where can one find more information about BridgeBio's programs?

For more information, visit BridgeBio's official website or follow their social media channels for updates on their latest research and developments.

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