BioCryst Pharmaceuticals Reveals HRU Improvements with ORLADEYO

BioCryst Pharmaceuticals Introduces New HRU Findings

BioCryst Pharmaceuticals, Inc. has recently shared compelling evidence regarding their product, ORLADEYO (berotralstat), that highlights its impact on reducing healthcare resource utilization for patients suffering from hereditary angioedema (HAE). This important finding underscores the therapy's role not only in individual patient care but also in enhancing the efficiency of the healthcare system.

Significant Evidence Presented at Industry Event

In a recent presentation, BioCryst revealed a study indicating substantial reductions in medical visits and hospitalizations among HAE patients after starting treatment with ORLADEYO. This data will be shared in detail at the upcoming Academy of Managed Care Pharmacy (AMCP) Nexus event, a leading national meeting for healthcare and pharmacy professionals.

Understanding the Study's Findings

The findings from a retrospective study analyzed administrative claims data from a myriad of insurance plans. The subjects of this study were 260 patients who had continuous health coverage for at least six months before initiating treatment with ORLADEYO. The outcomes were striking and pointed to a general trend of reduced healthcare demands following the initiation of this innovative therapy.

Key Reductions in Healthcare Resource Utilization

The data showed that after starting ORLADEYO, patients experienced:

• A 34 percent decrease in all-cause hospitalizations and a 14 percent reduction in emergency room visits.
• A 52 percent reduction in hospitalizations specifically related to angioedema and a remarkable 44 percent drop in related emergency room visits.

Additionally, HAE attack-related incidents saw a significant decline, with a 51 percent reduction in visits for these specific events.

On-Demand Therapy Usage Declines

Patients also reported a notable decrease in reliance on on-demand therapies, with a 39 percent reduction in the related medical procedures. These findings suggest that ORLADEYO not only aids in preventing acute issues but also streamlines the overall treatment process for HAE patients.

About ORLADEYO: A Breakthrough Treatment

ORLADEYO stands out as the first oral medication designed specifically for the prevention of HAE attacks. It requires only one capsule daily, simplifying the treatment regimen for both adults and children aged 12 and older. This innovative therapy primarily functions by inhibiting the action of plasma kallikrein, thus stabilizing patients against HAE attacks.

Important Safety Information to Consider

While ORLADEYO has shown promising results, it's crucial to consider safety aspects and indications. The therapy is not approved for treating acute HAE attacks, and patients with certain medical conditions may require adjusted dosages. Common adverse effects experienced by patients include abdominal discomfort and gastroesophageal reflux, which should be monitored closely.

BioCryst's Commitment to Rare Disease Innovation

BioCryst's dedication to addressing rare diseases is evident in their ongoing research and development efforts. The company's expertise in drug design has given rise to ORLADEYO, and they are continuously working on expanding their pipeline to serve various medical needs in the realm of rare diseases.

Frequently Asked Questions

What is ORLADEYO used for?

ORLADEYO is used as a prophylactic treatment to prevent attacks of hereditary angioedema in patients aged 12 and older.

How does ORLADEYO work?

It works by inhibiting plasma kallikrein, a protein involved in the pathways leading to angioedema attacks, thus reducing the frequency of these occurrences.

What were the highlights of the recent study presented by BioCryst?

The study highlighted significant reductions in hospitalizations, emergency visits, and the use of on-demand therapies among HAE patients after starting ORLADEYO.

Where can I learn more about BioCryst and ORLADEYO?

More information can be found on BioCryst’s official website, which provides comprehensive details about their products and ongoing research.

Are there any safety concerns with ORLADEYO?

While generally safe, patients should be aware of potential side effects such as abdominal pain and the importance of not using it for acute HAE attacks.

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