BioArctic Partners with Bristol Myers Squibb for New Therapies

BioArctic Enters Global License Agreement with Bristol Myers Squibb

BioArctic AB (publ) (Nasdaq Stockholm: BIOA B) has entered into a significant global exclusive licensing agreement with Bristol Myers Squibb (NYSE: BMY) aimed at adopting innovative solutions for Alzheimer's disease treatment. This strategic partnership targets BioArctic's groundbreaking PyroGlutamate-amyloid-beta (PyroGlu-A?) antibody program, which includes the promising antibodies BAN1503 and BAN2803, harnessing BioArctic's unique BrainTransporter™ technology.

Financial Details of the Agreement

This agreement lays the groundwork for a robust financial framework. BioArctic will receive an upfront payment of USD 100 million, with potential milestone payments that could reach up to USD 1.25 billion. Furthermore, the collaboration includes tiered low double-digit royalties on global sales of the product, marking a significant opportunity for BioArctic to expand its financial leverage in the biopharma sector.

Development and Commercialization Responsibilities

Under this agreement, Bristol Myers Squibb assumes full responsibility for the development and commercialization of the antibodies worldwide. BioArctic maintains an option to co-commercialize the products specifically in the Nordic region, allowing the company to maintain a vested interest in the product's performance in select markets.

Technology Behind PyroGlu-A? Antibody Program

The innovations behind the PyroGlu-A? antibody program focus on novel antibodies designed to combat a modified form of amyloid-beta, which has been shown to contribute to the detrimental effects of Alzheimer's disease. PyroGlu-A? monomers are notorious for their tendency to aggregate into harmful structures that impair cognitive abilities.

BrainTransporter Technology Explained

One of the key advancements in this collaboration is BioArctic's patented BrainTransporter technology. The blood-brain barrier (BBB) has historically posed challenges for biotherapeutics, particularly large molecules like antibodies. The BrainTransporter technology utilizes active transport methods to engage the transferrin receptor (TfR), thus facilitating more efficient delivery of drugs to the brain. This novel technology enhances the uptake of therapeutic agents, aiming to improve drug efficacy while minimizing side effects.

Insights from the Leadership

Gunilla Osswald, CEO of BioArctic, expressed enthusiasm about the partnership, stating, "This agreement with Bristol Myers Squibb reflects their commitment to advancing treatments for Alzheimer's disease. Their expertise and shared vision for patient care will be pivotal in realizing the potential of our innovative technologies."

Richard Hargreaves, Senior Vice President at Bristol Myers Squibb, also commented, emphasizing the potential of this partnership to reinforce their neuroscience portfolio. He stated, "We are excited to collaborate with BioArctic to explore transformative solutions for Alzheimer's disease, leveraging their BrainTransporter technology to optimize our approach to anti-amyloid-beta antibody treatments."

Potential Future Collaborations

This agreement not only represents a landmark deal for the PyroGlu-A? antibody treatments but also positions BioArctic favorably for future collaborations. The BrainTransporter technology holds promise for a variety of therapeutic areas, thereby expanding BioArctic's scope within the biopharmaceutical landscape.

About BioArctic

BioArctic AB (publ) stands at the forefront of biopharmaceutical innovation, especially concerning neurodegenerative diseases. The company has a rich pipeline of projects aimed at tackling conditions like Alzheimer's disease, with notable advancements such as Leqembi (lecanemab), the first drug proven to slow disease progression in early Alzheimer's cases, developed in collaboration with Eisai. With ongoing projects including antibodies targeting Parkinson's disease and ALS, BioArctic continues to push the envelope on neurodegenerative treatment possibilities.

Frequently Asked Questions

What is the recent agreement between BioArctic and Bristol Myers Squibb?

BioArctic has entered a global licensing agreement with Bristol Myers Squibb for its innovative PyroGlu-A? antibody program, focusing on Alzheimer's treatment.

What are the financial benefits of this agreement for BioArctic?

BioArctic will receive an upfront payment of USD 100 million, along with potential milestone payments of up to USD 1.25 billion, plus royalties on global sales.

What is the significance of the BrainTransporter technology?

The BrainTransporter technology facilitates the transport of therapeutic agents across the blood-brain barrier, enhancing drug delivery to the brain and improving treatment efficacy.

Who is responsible for the development and commercialization of the products?

Bristol Myers Squibb is solely responsible for the development and commercialization of the BAN1503 and BAN2803 products worldwide.

What is the future outlook for BioArctic's therapies?

This partnership positions BioArctic for potential future collaborations and innovations in various therapeutic areas beyond Alzheimer's disease, leveraging its proprietary technologies.

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