BeyondSpring Leverages $35.4 Million from SEED Partners

BeyondSpring Announces Equity Interest Sale for Growth

BeyondSpring Inc. (NASDAQ: BYSI), a clinical-stage biopharmaceutical company focused on innovative cancer therapies, has recently entered into significant agreements with SEED Therapeutics Inc. Selling a portion of its Series A-1 Preferred Shares, the company is set to raise approximately $35.4 million. With this exit strategy, BeyondSpring is expected to retain around 14.4% of SEED’s outstanding shares, positioning itself advantageously for future growth.

Innovative Foundations in Targeted Protein Degradation

BeyondSpring has been a pioneer in Targeted Protein Degradation (TPD) innovation since its inception in 2016. SEED Therapeutics, co-founded by BeyondSpring and Eli Lilly in 2020, focuses on developing breakthroughs within TPD. This revolutionary drug discovery strategy aims at addressing proteins that have historically been deemed undruggable, showcasing significant advancements in the treatment of various diseases, particularly in oncology.

Strategic Collaborations Powered by Leading Partners

SEED’s robust partnerships with pharmaceutical giants including Eli Lilly and Eisai Co., Ltd. emphasize its commitment to innovation. Recent financing rounds, particularly the Series A-3 led by Eisai, with a pre-money valuation of $100 million, illustrate SEED's growth potential in the biotech sector. The funds from BeyondSpring’s equity sale will be allocated primarily towards supporting the advanced clinical trials of Plinabulin, a promising agent in cancer treatment, ensuring resources are available without diluting shareholder equity.

Plinabulin: A Revolutionary Cancer Fighting Agent

As a first-in-class therapy, Plinabulin has already been administered to more than 700 patients with positive outcomes and notable tolerability. Notably, this anti-cancer agent acts as a unique tubulin binder that triggers immune defense mechanisms, thereby promoting cell maturation and effectively activating the immune system against cancerous cells. Research indicates its efficacy in reducing risks associated with existing treatment protocols.

Positive Clinical Trial Results Highlighting Efficacy

Plinabulin's performance in various studies reinforces its potential:

• DUBLIN-3 (103) Study: This Phase 3 trial showcased remarkable survival benefits for patients with EGFR wild-type non-small-cell lung cancer (NSCLC) when Plinabulin was combined with docetaxel.
• 303 Study: Here, Plinabulin, in combination with pembrolizumab and docetaxel, demonstrated an impressive disease control rate and extended median progression-free survival.
• 302 Study: The enrollment of extended-stage small cell lung cancer (ES-SCLC) patients represents a valuable trial area, testing Plinabulin's utility in combination with established chemotherapies.

Dr. Trevor Feinstein from Piedmont Cancer Center voiced critical insights on the challenges NSCLC patients face, emphasizing the urgency of advancing Plinabulin research. Across studies, Plinabulin has displayed a favorable risk-benefit ratio, standing apart from traditional therapies that often fail to meet survival expectations.

Strategic Vision for Future Clinical Trials

With fresh capital from the recent SEED equity sale, BeyondSpring is poised to accelerate its promising pipeline. Dr. Lan Huang, Co-Founder and CEO, expressed confidence in utilizing the funding for Plinabulin's combination studies with immune checkpoint inhibitors, potentially leading to lucrative partnerships aimed at expanding access to this innovative treatment.

Commitment to Transforming Cancer Care

By retaining a stake in SEED Therapeutics, BeyondSpring ensures it remains central to the advances in TPD, reinforcing its commitment to tackling high unmet medical needs. The innovative nature of its pipeline, including both Plinabulin and emerging candidates, keeps BeyondSpring at the forefront of the biopharmaceutical landscape.

Frequently Asked Questions

What recent agreement did BeyondSpring announce?

BeyondSpring announced entering definitive agreements to sell a portion of its Series A-1 Preferred Shares in SEED Therapeutics for $35.4 million.

What is Plinabulin, and how does it work?

Plinabulin is a first-in-class anti-cancer agent that acts as a tubulin binder, stimulating immune defense mechanisms and promoting cell maturation in cancer treatment.

How does the financing from SEED impact BeyondSpring's future?

The financing allows BeyondSpring to advance late-stage clinical trials for Plinabulin without diluting shareholder equity, positioning it favorably for growth.

What have clinical studies shown about Plinabulin's efficacy?

Clinical studies have indicated Plinabulin enhances survival rates in non-small-cell lung cancer patients and shows favorable results when combined with existing therapies.

What is BeyondSpring's strategic vision with SEED Therapeutics?

BeyondSpring aims to leverage its stake in SEED to drive advancements in targeted protein degradation therapies and strengthen its presence in the biopharmaceutical sector.

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