Basilea Enters Distribution Agreement for Zevtera in the US

Basilea's Exciting New Partnership

Basilea Pharmaceutica Ltd has made a significant stride in fighting severe bacterial infections by entering an exclusive distribution and licensing agreement with Innoviva Specialty Therapeutics, a wholly owned subsidiary of Innoviva Inc. The partnership focuses on distributing Basilea's advanced anti-MRSA antibiotic, Zevtera (ceftobiprole), in the United States. This collaboration aims to enhance treatment options available to patients facing complicated infections, marking an important step in Basilea's growth trajectory.

Innoviva: A Strong Partner

Innoviva Specialty Therapeutics comes equipped with a robust hospital sales force and is well-versed in bringing anti-infective medicines to the market. David Veitch, Chief Executive Officer of Basilea, expressed enthusiasm about this collaboration, highlighting Innoviva's commitment and capability, which align closely with Basilea’s goals. Both companies share a vision for effectively introducing Zevtera to the US market, ensuring that patients who need it most will have access to this crucial medication.

Innoviva's Vision for Zevtera

Pavel Raifeld, the Chief Executive Officer of Innoviva, underscored the medical necessity of treatments focused on complicated Staphylococcus aureus infections. The urgency is particularly pronounced for infections like Staphylococcus aureus bacteremia that can lead to severe complications. Through this agreement, Zevtera will play a pivotal role in the company's portfolio, aligning with their mission to deliver innovative therapeutics within the infectious disease and critical care sectors.

Financial Aspects of the Agreement

The agreement stipulates an upfront payment of USD 4 million to Basilea, along with tiered royalties from net sales expected to range in the high-teens to mid-twenties percentage. Basilea could also earn sales milestones that could accumulate to USD 223 million. Furthermore, Innoviva Specialty Therapeutics will source their demand of Zevtera directly from Basilea, solidifying a mutually beneficial relationship.

Zevtera: Innovative Antibiotic Treatment

Zevtera, a cutting-edge antibiotic developed for intravenous use, is well-equipped to combat a variety of Gram-positive and Gram-negative bacteria. Its rapid bactericidal properties make it particularly effective against difficult-to-treat infection strains, including methicillin-resistant Staphylococcus aureus (MRSA). Currently, Zevtera is marketed in various countries, addressing critical hospital-acquired and community-acquired infections.

Clinical Applications and Development

In the US, Zevtera holds indications for treating adult patients with Staphylococcus aureus bloodstream infections (bacteremia) and acute bacterial skin and skin structure infections. Additionally, it’s appropriate for pediatric patients aged 3 months to less than 18 years suffering from community-acquired bacterial pneumonia. Basilea’s commitment to addressing such severe infections is further evidenced by its phase 3 program, which receives federal funding from the US Department of Health and Human Services and related authorities to support its ambitious research and development initiatives.

Basilea’s Commitment to Infection Treatment

Founded in 2000, Basilea Pharmaceutica Ltd has positioned itself as a dedicated player within the biopharmaceutical industry, concentrating on developing and commercializing drugs for the treatment of severe infections. With products like Cresemba, aimed at fungal infections, and now Zevtera, Basilea is committed to providing effective therapies where they're needed most. The company continues to innovate, holding numerous agreements across more than 80 countries to extend its reach and impact globally.

Conclusion: A Bright Future Ahead

The partnership between Basilea and Innoviva represents a promising development for patients battling serious bacterial infections. By leveraging each other's strengths, the companies are poised to enhance the treatment landscape in the US effectively. This collaboration demonstrates Basilea’s dedication to combating critical healthcare challenges and highlights Innoviva's commitment to launching vital therapies that respond to pressing medical needs.

Frequently Asked Questions

What is Zevtera?

Zevtera is an advanced cephalosporin antibiotic developed by Basilea, effective against Gram-positive bacteria including MRSA.

What is the purpose of the agreement with Innoviva?

The agreement enables Innoviva to exclusively distribute Zevtera in the US, enhancing patient access to this vital medication.

How much will Basilea receive from Innoviva?

Basilea will receive a USD 4 million upfront payment plus tiered royalties on net sales and could earn up to USD 223 million in sales milestones.

What infections does Zevtera treat?

Zevtera is indicated for treating severe infections such as Staphylococcus aureus bacteremia and acute bacterial skin infections.

What is Basilea's vision for future treatments?

Basilea aims to discover, develop, and commercialize innovative therapies to address severe bacterial and fungal infections globally.

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