Avalo Therapeutics Welcomes Jennifer Riley as Chief Strategy Officer

Avalo Therapeutics Expands Leadership Team with Jennifer Riley

WAYNE, Pa. and ROCKVILLE, Md. – Avalo Therapeutics, Inc. (Nasdaq: AVTX), a clinical stage biotechnology company dedicated to addressing immune dysregulation, has exciting news regarding its leadership. Jennifer Riley has been appointed as the new Chief Strategy Officer, a pivotal role aimed at enhancing corporate strategy and product planning. This strategic move showcases Avalo's commitment to growth and innovation in the healthcare sector.

Insights from Leadership

Dr. Garry Neil, Chief Executive Officer and Chairman of the Board at Avalo, expressed enthusiasm about Ms. Riley's appointment. He stated, "We are thrilled to welcome Jennifer to Avalo in the newly established role of Chief Strategy Officer. Jennifer brings extensive leadership experience, strategic acumen, and deep expertise in immunology, which will be invaluable as we advance our lead asset, AVTX-009, an anti-IL-1? monoclonal antibody currently in a critical clinical trial for hidradenitis suppurativa (HS)." This statement underlines the importance of her role, especially as the firm seeks to optimize their commercialization strategies.

Ms. Riley's Vision

Jennifer Riley voiced her excitement about joining Avalo during this transformative period for the company. As she steps into her new position, she aims to capitalize on the promising potential of AVTX-009 as it targets hidradenitis suppurativa, a condition with significant unmet medical needs. Highlighting the extensive therapeutics market, projected to surpass $10 billion, Ms. Riley noted, "I look forward to collaborating with the talented team at Avalo to advance the company’s mission of delivering impactful therapies that address immune dysregulation and improve the lives of patients in need." Her leadership is expected to guide Avalo through its next phase of growth.

Riley's Background and Qualifications

With over two decades of experience in the biotechnology and pharmaceutical industries, Ms. Riley adds a wealth of knowledge and expertise to her new role. Previously, she founded Northbrook Consulting, aiding over 30 organizations in development strategies, commercialization, and portfolio management. Additionally, her tenure at Biogen included significant responsibilities, where she oversaw the strategy and launch readiness for their hemophilia portfolio. Her impressive track record also includes advancing various product pipelines across therapeutic areas, notably immunology and rare diseases.

Inducement Grants for New Leadership

In alignment with her employment agreement, Avalo's Board of Directors has approved an enticing inducement grant for Ms. Riley. This includes a non-qualified stock option to purchase 150,000 shares of Avalo’s common stock, which will vest over four years. Such initiatives demonstrate Avalo’s commitment to incentivizing their new leadership while aligning their goals with the company's long-term success.

About Avalo Therapeutics

Avalo Therapeutics excels in developing therapies that target immune dysregulation. Their lead asset, AVTX-009, operates as an anti-IL-1? monoclonal antibody, showing promise for inflammatory diseases. Additionally, Avalo is advancing other candidates like quisovalimab (anti-LIGHT mAb) and AVTX-008 (BTLA agonist). The company is at the forefront of advancing potential treatments for conditions with limited therapies.

Understanding AVTX-009 and Its Potential

AVTX-009 plays a significant role in targeting IL-1?, a key driver in many inflammatory pathways. Given the dysregulation of IL-1? is linked to various autoimmune conditions, the prospects for AVTX-009 not only in HS but also in broader inflammatory diseases remain promising. Clinical evidence supports the efficacy of IL-1? inhibition in treating disorders beyond HS.

The LOTUS Trial: A Step Towards New Treatments

The LOTUS Trial stands as a major endeavor for Avalo, designed to evaluate AVTX-009's safety and efficacy among approximately 180 adults experiencing moderate to severe hidradenitis suppurativa. This pivotal study promises valuable insights into the treatment's impact while adhering to rigorous clinical standards. The trial aims to show clinical response improvements from participating patients, and continues to pave the way for innovative therapeutic interventions.

Understanding Hidradenitis Suppurativa

Hidradenitis suppurativa is not just a skin condition; it's a chronic inflammatory disorder causing substantial distress to affected individuals. Characterized by painful abscesses and nodules, this condition profoundly interferes with daily life and requires specialized therapeutic approaches. Acknowledging the challenges associated with HS, Avalo aims to address these needs and improve patient outcomes through targeted therapies like AVTX-009.

Frequently Asked Questions

What is Avalo Therapeutics known for?

Avalo Therapeutics specializes in developing therapies for immune dysregulation with a focus on innovative treatments such as AVTX-009.

Who has been appointed as Chief Strategy Officer at Avalo?

Jennifer Riley has been appointed as the Chief Strategy Officer at Avalo Therapeutics.

What is the significance of AVTX-009?

AVTX-009 targets IL-1?, which is crucial in managing inflammatory diseases, particularly hidradenitis suppurativa.

What is the LOTUS Trial?

The LOTUS Trial evaluates the efficacy and safety of AVTX-009 in treating hidradenitis suppurativa among adult participants.

What are the therapeutic goals of Avalon?

Avalo aims to deliver innovative therapies that effectively manage immune dysregulation and improve the quality of life for patients in need.

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