Atossa Therapeutics Strengthens Patent Portfolio with New Scope
Atossa Therapeutics Strengthens Patent Portfolio
Atossa Therapeutics, Inc. (Nasdaq: ATOS) has made significant strides in its mission to develop innovative treatments for breast cancer. The company recently announced a key development: the granting of a new patent, U.S. Patent No. 12,275,684, by the United States Patent and Trademark Office. This patent focuses on enteric oral formulations that incorporate (Z)-endoxifen, a potent compound with the potential to reshape treatments for breast cancer.
Understanding (Z)-Endoxifen
(Z)-endoxifen is recognized as one of the most effective Selective Estrogen Receptor Modulators (SERMs). Its unique capabilities extend beyond simple estrogen receptor inhibition; it may induce degradation of these receptors. Such qualities make it a promising candidate, especially in patients who have developed resistance to traditional hormonal therapies.
Clinical Applications of (Z)-Endoxifen
The implications of this compound are extensive. Research shows that (Z)-endoxifen can effectively target oncogenic proteins like PKC?1 at blood concentrations achievable through oral administration. This offers a multi-faceted approach, one that not only aims at controlling cancer growth but also considers the overall well-being of patients. Notably, (Z)-endoxifen appears to provide beneficial bone effects while minimizing concerns typically associated with other treatments, such as endometrial proliferation seen with tamoxifen.
Advancements in Intellectual Property
With the new patent secured, Atossa has fortified its intellectual property strategy surrounding (Z)-endoxifen significantly. The company’s patent estate now comprises multiple U.S. patents, covering over 100 claims related specifically to its (Z)-endoxifen formulations and their applications in clinical settings. This comprehensive protective measure underscores Atossa's commitment to lead the development of targeted therapies for hormone receptor-positive breast cancer and enhances company stability.
Benefits of Enteric Formulation
Atossa's innovative approach involves creating an oral formulation of (Z)-endoxifen that's encapsulated to bypass the stomach. This is crucial, as stomach acidity can convert a significant amount of (Z)-endoxifen into its inactive form, (E)-endoxifen. Early clinical trials have revealed that this formulation is well-tolerated among both breast cancer patients and those without the disease, indicating a promising avenue for treatment and prevention.
Atossa’s Commitment to Breast Cancer Treatment
The dedication of Atossa Therapeutics to transform breast cancer treatment is evident in its robust research and development initiatives. Its lead therapeutic candidate, (Z)-endoxifen, holds potential applications across the entire spectrum of breast cancer treatment strategies: from prevention to advanced stages of the disease. Atossa emphasizes creating patient-centered solutions while striving to enhance patient outcomes and create sustainable shareholder value.
Recent Clinical Studies and Future Directions
In ongoing studies, (Z)-endoxifen is being explored not only for treatment but also for preventive measures against breast cancer, including trials involving metastatic forms of the disease. With the evolving landscape of cancer therapies, Atossa is positioning itself as a trailblazer in the development of innovative treatments aimed at addressing pressing medical needs.
Frequently Asked Questions
What is (Z)-endoxifen and how does it work?
(Z)-endoxifen is a potent SERM that inhibits estrogen receptors and promotes their degradation, offering a promising option for those resistant to conventional therapies.
What recent patent was granted to Atossa Therapeutics?
Atossa Therapeutics was granted U.S. Patent No. 12,275,684 for enteric oral formulations of (Z)-endoxifen, enhancing its intellectual property coverage.
How does Atossa's new patent affect its business strategy?
The patent reinforces Atossa's commitment to innovation and establishes a stronger market position in developing targeted breast cancer therapies.
What clinical applications are being explored for (Z)-endoxifen?
Atossa is investigating (Z)-endoxifen for use in breast cancer treatment and prevention across various stages, including metastatic cases.
What is Atossa Therapeutics' overall mission?
Atossa aims to transform breast cancer treatment through innovative science and patient-focused solutions, striving for enhanced patient outcomes and shareholder value.
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