Ascendis Pharma Showcases Promising Ovarian Cancer Findings
Ascendis Pharma Reports Initial Data on Ovarian Cancer Treatment
Ascendis Pharma A/S (NASDAQ: ASND) has recently shared encouraging initial findings concerning its ongoing Phase 1/2 IL-Believe Trial. This trial investigates the efficacy of TransCon IL-2 ?/? when combined with chemotherapy in patients suffering from platinum-resistant ovarian cancer (PROC). These findings will be presented at ESMO 2024, an annual event held by the European Society of Medical Oncology.
Key Findings from the Trial
Among the 18 patients enrolled in the study, a group of 14 was identified as efficacy-evaluable. Notably, anti-tumor responses were observed in 29% of these patients, translating into four positive outcomes. These patients had faced numerous lines of treatment, ranging from three to seven prior therapies.
The results suggest that treatment with TransCon IL-2 ?/? combined with chemotherapy could offer new hope for individuals with PROC, particularly those who have exhausted other treatment options. Furthermore, the safety profile of the treatment appears reassuring, with most observed adverse effects being mild to moderate in severity.
Continuing Research and Future Updates
Stina Singel, M.D., Ph.D., the Executive Vice President, emphasized the significance of these initial results. She expressed excitement about the observed anti-tumor activity in this heavily pre-treated group, highlighting the potential for this combination therapy to change treatment paradigms.
Further updates from the ongoing trial are anticipated, as the clinical team continues monitoring participant responses and the safety of the treatments. Existing data showcases a favorable tolerability profile, as adverse events primarily consisted of fatigue, thrombocytopenia, neutropenia, and anemia, predominantly classified as grade 1 or 2.
About TransCon IL-2 ?/? and IL-Believe Trial
TransCon IL-2 ?/? is a novel therapeutic agent designed to activate the immune response against tumors. This innovative compound functions by releasing an IL-2 analogue in a controlled manner, optimizing the treatment's effectiveness while reducing potential side effects. The Phase 1/2 IL-Believe study includes multiple cohorts aimed at assessing the treatment's impact across various types of solid tumors.
As of the latest data collection, 42 patients with PROC have been enrolled in the dedicated dose expansion cohort. Treatment protocols involved administering TransCon IL-2 ?/? alongside usual chemotherapy options like paclitaxel or docetaxel at specified intervals.
Company Overview and Future Aspirations
Ascendis Pharma, headquartered in Copenhagen, Denmark, is dedicated to leveraging its TransCon technology platform to revolutionize treatment options across various medical indications. Guided by principles centered on patient care, scientific advancement, and passionate innovation, the firm aims to deliver therapies that significantly improve patients' lives.
This commitment is reflected in their pipeline of potential treatments, designed not only to address current medical challenges but also to enhance the therapeutic landscape in oncology. As research progresses, Ascendis Pharma looks forward to evaluating the overall impact of these promising findings on cancer care.
Frequently Asked Questions
What is the focus of the Phase 1/2 IL-Believe Trial?
The trial looks into the effectiveness of TransCon IL-2 ?/? combined with chemotherapy for treating platinum-resistant ovarian cancer.
What were the initial findings presented by Ascendis Pharma?
Initial results indicated anti-tumor responses in 29% of patients treated with TransCon IL-2 ?/? in combination with chemotherapy.
How were the treatments tolerated in the study?
The treatments showed a favorable safety profile, with mild to moderate side effects predominantly related to fatigue, thrombocytopenia, and similar conditions.
What kind of patients are being enrolled in this trial?
Patients included in this study are those with platinum-resistant ovarian cancer who have already undergone multiple lines of previous treatment.
What is the mission of Ascendis Pharma?
Ascendis Pharma aims to utilize its innovative technologies to create effective therapies that transform patient outcomes worldwide, particularly in oncology.
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