AP Biosciences Showcases Groundbreaking Antibody Data for Cancer

AP Biosciences Showcases Groundbreaking Antibody Data for Cancer

AP Biosciences, a pioneering entity in the biopharmaceutical sector, has made significant strides in cancer therapy innovation. The company has recently shared transformative preclinical data regarding its lead therapeutic candidate, AP402, highlighting its potential to revolutionize treatment for HER2-positive cancers.

Presentation Highlights at AACR Annual Meeting

During a prominent annual scientific gathering, the American Association for Cancer Research Annual Meeting, AP Biosciences unveiled compelling evidence supporting AP402's capacity to engage T-cell activity effectively. The poster presentation, titled "AP402, a bispecific antibody targeting p95HER2 and CD137, shows potent antitumor activity," focused on the antibody's unique ability to target cancer cells that have developed resistance to existing therapies.

The Significance of p95HER2 Targeting

AP402 is specifically designed to target p95HER2, a truncated form of the HER2 protein often linked with poor treatment outcomes in patients resistant to standard therapies, notably Trastuzumab (Herceptin). This innovation opens new avenues for therapy as it caters to approximately 30-40% of individuals suffering from HER2-positive breast cancer.

Key Findings from Preclinical Studies

• High Binding Affinity: The data indicated that AP402 demonstrates exceptional specificity for p95HER2, binding preferentially to this isoform compared to its full-length counterpart.
• Robust T-Cell Activation: Co-culture studies revealed that AP402 promotes significant secretion of IFN-? from T-cells, showcasing enhanced activation corresponding to p95HER2 presence on target cells. Notably, it outperformed traditional combination therapies using singular antibodies.
• Broad Cell Line Efficacy: AP402 prompted remarkable IFN-? responses across various p95HER2-expressing cancer cell lines, suggesting its wide-ranging applicability therapeutically.
• Effective ADCC Response: The antibody triggered a dose-dependent activation of Antibody-Dependent Cellular Cytotoxicity (ADCC) in relevant cancer cell lines, showcasing strong relationships between cytotoxicity and p95HER2 expression levels.
• Engagement of Innate Immunity: In vitro findings demonstrated that AP402 effectively stimulated macrophage-induced phagocytosis of p95HER2-positive cells, emphasizing its ability to utilize innate immune strategies.
• Promising Xenograft Model Results: Evidence was also presented showing that AP402 led to substantial tumor regression in both cell line-derived and patient-derived xenograft models of breast cancer.
• Safety Profile: Testing in cynomolgus monkeys reflected a favorable pharmacokinetic profile with no significant adverse effects, indicating a solid safety aspect at higher doses.

The Path Forward for AP402

Given these encouraging preclinical outcomes, the journey of AP402 is set to progress into clinical assessment. The collaborative team at AP Biosciences, led by Dr. Jeng Her, the CEO, is optimistic about the potential of AP402 to alleviate considerable patient suffering associated with resistant cancers.

Understanding AP402 and Its Mechanism

With a focus on the innovative features of AP402, it stands as a first-in-class bispecific antibody engineered to activate T-cells at the cancer site. The synergy between its dual target mechanism allows for minimized systemic toxicity—a common challenge in cancer therapies. The engineering of the binding domains facilitates effective immune response mobilization in the immediate environment of tumors, thus offering a tailored approach to treatment.

Company Overview

AP Biosciences is headquartered in Taiwan and is dedicated to developing cutting-edge antibody-based treatments for various diseases, primarily focusing on cancer. The integration of their proprietary Omni-Mab and T-cube platforms positions AP Biosciences at the forefront of the biotechnology industry. They strive to improve and expand therapeutic options for patients battling challenging cancers.

Contact Information

For further inquiries, please reach out to:

Spike Lo
AP Biosciences
Email: pr@apbioinc.com
Phone: +886-2-2653-2886

Media inquiries can be directed to:

Jason Braco, PhD
LifeSci Communications
Email: jbraco@lifescicomms.com
Phone: (908)-432-4243

Frequently Asked Questions

What is AP402?

AP402 is a bispecific antibody targeting p95HER2 and CD137, designed to enhance immune response against HER2-positive cancers.

Why is p95HER2 significant?

p95HER2 is a truncated form of the HER2 protein that is linked to treatment resistance in approximately 30-40% of breast cancer patients.

What were the main findings from the preclinical studies?

Key findings showed AP402's strong specificity for target cells, robust T-cell activation, and effective antitumor responses in various models.

What is the future outlook for AP402?

With promising preclinical data, AP402 is expected to move forward into clinical trials aimed at evaluating its safety and efficacy in patients.

How can I contact AP Biosciences for more information?

You can contact Spike Lo at AP Biosciences via email at pr@apbioinc.com or call +886-2-2653-2886 for inquiries.

About The Author

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